内质网应激蛋白ATF4调控STAT3信号通路促进黑色素瘤细胞生长及转移的研究(4)
[12]Ameri K，Lewis CE，Raida M，et al.Anoxic induction of ATF-4 through HIF-1-independent pathways of protein stabilization in human cancer cells[J].Blood，2004，103(5)：1876-1882.
[13]Dey S，Sayers CM，Verginadis II，et al. ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis[J].J Clin Invest，2015，125(7)：2592-2608.
[14]Suzuki T，Osumi N，Wakamatsu Y.Stabilization of ATF4 protein is required for the regulation of epithelial-mesenchymal transition of the avian neural crest[J].Dev Biol，2010，344(2)：658-668.
[15]Nagelkerke A，Bussink J，Mujcic H，et al.Hypoxia stimulates migration of breast cancer cells via the PERK/ATF4/LAMP3-arm of the unfolded protein response[J].Breast Cancer Res，2013，15(1)：R2.
[16]Croft A，Tay KH，Boyd SC，et al.Oncogenic activation of MEK/ERK primes melanoma cells for adaptation to endoplasmic reticulum stress[J].J Invest Dermatol，2014，134(2)：488-497.
[17]Ma XH，Piao SF，Dey S，et al.Targeting ER stress-induced autophagy overcomes BRAF inhibitor resistance in melanoma[J].J Clin Invest，2014，124(3)：1406-1417.
[18]Shan B，Wang X，Wu Y，et al.The metabolic ER stress sensor IRE1alpha suppresses alternative activation of macrophages and impairs energy expenditure in obesity[J]. Nat Immunol，2017，18(5)：519-529.
[19]Shao M，Shan B，Liu Y，et al.Hepatic IRE1alpha regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARalpha axis signalling[J].Nat Commun，2014，5：3528.
[20]Ding BB，Yu JJ，Yu RY，et al.Constitutively activated STAT3 promotes cell proliferation and survival in the activated B-cell subtype of diffuse large B-cell lymphomas[J].Blood，2008，111(3)：1515-1523.
[21]Darnell JE.Validating Stat3 in cancer therapy[J].Nat Med，2005，11(6)：595-596.
[22]Kortylewski M，Jove R，Yu H.Targeting STAT3 affects melanoma on multiple fronts[J].Cancer Metastasis Rev，2005，24(2)：315-327.
[23]Kortylewski M，Kujawski M，Wang T，et al.Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity[J].Nat Med，2005，11(12)：1314-1321.
[收稿日期]2018-04-28 [修回日期]2018-05-28
編辑/朱婉蓉, http://www.100md.com(张学军 亓发芝)
[13]Dey S，Sayers CM，Verginadis II，et al. ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis[J].J Clin Invest，2015，125(7)：2592-2608.
[14]Suzuki T，Osumi N，Wakamatsu Y.Stabilization of ATF4 protein is required for the regulation of epithelial-mesenchymal transition of the avian neural crest[J].Dev Biol，2010，344(2)：658-668.
[15]Nagelkerke A，Bussink J，Mujcic H，et al.Hypoxia stimulates migration of breast cancer cells via the PERK/ATF4/LAMP3-arm of the unfolded protein response[J].Breast Cancer Res，2013，15(1)：R2.
[16]Croft A，Tay KH，Boyd SC，et al.Oncogenic activation of MEK/ERK primes melanoma cells for adaptation to endoplasmic reticulum stress[J].J Invest Dermatol，2014，134(2)：488-497.
[17]Ma XH，Piao SF，Dey S，et al.Targeting ER stress-induced autophagy overcomes BRAF inhibitor resistance in melanoma[J].J Clin Invest，2014，124(3)：1406-1417.
[18]Shan B，Wang X，Wu Y，et al.The metabolic ER stress sensor IRE1alpha suppresses alternative activation of macrophages and impairs energy expenditure in obesity[J]. Nat Immunol，2017，18(5)：519-529.
[19]Shao M，Shan B，Liu Y，et al.Hepatic IRE1alpha regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARalpha axis signalling[J].Nat Commun，2014，5：3528.
[20]Ding BB，Yu JJ，Yu RY，et al.Constitutively activated STAT3 promotes cell proliferation and survival in the activated B-cell subtype of diffuse large B-cell lymphomas[J].Blood，2008，111(3)：1515-1523.
[21]Darnell JE.Validating Stat3 in cancer therapy[J].Nat Med，2005，11(6)：595-596.
[22]Kortylewski M，Jove R，Yu H.Targeting STAT3 affects melanoma on multiple fronts[J].Cancer Metastasis Rev，2005，24(2)：315-327.
[23]Kortylewski M，Kujawski M，Wang T，et al.Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity[J].Nat Med，2005，11(12)：1314-1321.
[收稿日期]2018-04-28 [修回日期]2018-05-28
編辑/朱婉蓉, http://www.100md.com(张学军 亓发芝)