鼠神经生长因子联合皮瓣修复术治疗电烧伤创面(1)
[摘要]目的：探讨鼠神经生长因子联合皮瓣修复术治疗电烧伤创面的临床效果。方法：选择2013年8月-2017年8月笔者医院就诊的90例电烧伤患者为研究对象，通过随机数表法分为观察组(n=46)和对照组(n=44)。对照组给予皮瓣修复术治疗，术后给予抗生素、维生素B12常规治疗；观察组在对照组基础上，联合鼠神经生长因子治疗。比较两组围手术期情况，治疗前、后神经传导速度的变化，感觉、运动功能改善情况及不良反应发生情况。结果：观察组创面愈合时间、住院时间、手术至出院时间及创面感染发生率均明显少于对照组，差异有统计学意义(P<0.05)。治疗后半年，两组感觉神经传导速度(Sensory nerve conduction velocity，SCV)、運动神经传导速度(Motor nerve conduction velocity，MCV)均较治疗前明显改善，观察组SCV、MCV均明显高于对照组[(43.84±3.18)m/s vs(39.05±3.02)m/s，(57.30±4.69)m/s vs(50.34±4.22)m/s]，差异有统计学意义(P<0.05)。观察组感觉功能优良率及运动功能优良率均优于对照组(89.13% vs 70.45%，86.96% vs 68.18%)，差异有统计学意义(P<0.05)。两组不良反应总发生率分别为8.70%和4.55%，组间比较差异无统计学意义(P>0.05)。结论：电烧伤创面应用鼠神经生长因子联合皮瓣修复术治疗效果显著，可有效修复神经损伤，促进肢体感觉、运动功能恢复，且不良反应少，用药安全性高。
, 百拇医药
[关键词]电烧伤；皮瓣修复术；鼠神经生长因子；神经传导速度
[中图分类号]R622 [文献标志码]A [文章编号]1008-6455(2018)09-0052-04
Treatment of Electric Burn Wounds with Rat Nerve Growth Factor Combined with Skin Flap Repair
ZUO Fei
(Department of Surgery，Nanjing Yangzi Hospital，Nanjing 210048，Jiangsu，China)
Abstract： Objective To study the curative efficacy of rat nerve growth factor combined with skin flap repair in treatment of electric burn wounds. Methods 90 patients of electric burn who received therapy from August 2013 to August 2017 in our hospital were selected as research objects， according to random number table， they were divided into the observation group (n=46) and the control group (n=46). The control group was treated with skin flap repair， and antibiotics and vitamin B12 were given routine treatment after operation. The observation group was combined with mouse nerve growth factor therapy on the basis of the control group. The perioperative conditions of the two groups were compared， and the changes of nerve conduction velocity before and after treatment， the sensation， motor function and adverse reactions were compared. Results The wound healing time， hospitalization time， operation to discharge time and wound infection rate in the observation group were significantly less than those in the control group， the differences were statistically significant(P<0.05). After half a year， sensory nerve conduction velocity (SCV) and motor nerve conduction velocity (MCV) in the two groups were significantly improved compared with those before treatment，and the SCV and MCV in the observation group were significantly higher than those in the control group[(43.84±3.18)m/s vs(39.05±3.02)m/s，(57.30±4.69)m/s vs(50.34±4.22)m/s]， the difference were statistical significance(P<0.05). The excellent rate of sensory function and motor function in the observation group were superior to those in the control group (89.13% vs 70.45%， 86.96% vs 68.18%)， the differences were statistically significant(P<0.05). The total incidence of adverse reactions in the two groups was 8.70% and 4.55% respectively， and there was no significant difference(P>0.05). Conclusion Rat nerve growth factor combined with skin flap repair is well for electric burn，which can effectively repair nerve injury， promote limb sensory and motor function recovery， and has fewer adverse reactions and high safety., 百拇医药(左飞)
, 百拇医药
[关键词]电烧伤；皮瓣修复术；鼠神经生长因子；神经传导速度
[中图分类号]R622 [文献标志码]A [文章编号]1008-6455(2018)09-0052-04
Treatment of Electric Burn Wounds with Rat Nerve Growth Factor Combined with Skin Flap Repair
ZUO Fei
(Department of Surgery，Nanjing Yangzi Hospital，Nanjing 210048，Jiangsu，China)
Abstract： Objective To study the curative efficacy of rat nerve growth factor combined with skin flap repair in treatment of electric burn wounds. Methods 90 patients of electric burn who received therapy from August 2013 to August 2017 in our hospital were selected as research objects， according to random number table， they were divided into the observation group (n=46) and the control group (n=46). The control group was treated with skin flap repair， and antibiotics and vitamin B12 were given routine treatment after operation. The observation group was combined with mouse nerve growth factor therapy on the basis of the control group. The perioperative conditions of the two groups were compared， and the changes of nerve conduction velocity before and after treatment， the sensation， motor function and adverse reactions were compared. Results The wound healing time， hospitalization time， operation to discharge time and wound infection rate in the observation group were significantly less than those in the control group， the differences were statistically significant(P<0.05). After half a year， sensory nerve conduction velocity (SCV) and motor nerve conduction velocity (MCV) in the two groups were significantly improved compared with those before treatment，and the SCV and MCV in the observation group were significantly higher than those in the control group[(43.84±3.18)m/s vs(39.05±3.02)m/s，(57.30±4.69)m/s vs(50.34±4.22)m/s]， the difference were statistical significance(P<0.05). The excellent rate of sensory function and motor function in the observation group were superior to those in the control group (89.13% vs 70.45%， 86.96% vs 68.18%)， the differences were statistically significant(P<0.05). The total incidence of adverse reactions in the two groups was 8.70% and 4.55% respectively， and there was no significant difference(P>0.05). Conclusion Rat nerve growth factor combined with skin flap repair is well for electric burn，which can effectively repair nerve injury， promote limb sensory and motor function recovery， and has fewer adverse reactions and high safety., 百拇医药(左飞)
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