改良A型肉毒毒素注射技术治疗外眦部皱纹的效果观察(1)
[摘要]目的：探讨一种改良A型肉毒毒素注射技术对外眦皱纹的矫正效果。方法：收集笔者医院门诊2018年10月-2019年7月收治的外眦皱纹患者，共45例，90侧，均采用A型肉毒毒素(美国保妥适)进行治疗，稀释后浓度为2U/0.1ml，每侧共注射8～15个点，每点注射0.5U，观察其临床效果和并发症。结果：所有患者注射3～7d后，外眦动态皱纹消失，均未出现瘀青、复视、斜视、笑容不对称等并发症，效果满意。结论：改良A型肉毒毒素注射技术对外眦部动力性皱纹有较好的效果，本注射方法疗效显著，副作用低，是一种注射除皱的理想方法，值得在临床上推广使用。
[关键性]A型肉毒毒素;外眦皱纹;改良技术;临床效果;满意度;并发症
[中图分类号]R622 [文献标志码]A [文章编号]1008-6455(2019)12-0011-03
Observation on the Effect of Modified Botulinum Toxin Type A Injection Technique in the Treatment of Lateral Canthus Wrinkles
YANG Mei，CHEN Chang-yong，LIN Huang，LI Bin-bin
(Department of Plastic Surgery and Laser，Beijing Anzhen Hospital Affiliated to Capital Medical University，Beijing 100029，China)
Abstract： Objective To observe the effect of modified botulinum toxin type A injection technique on lateral canthus wrinkle. Methods 45 cases with lateral canthus wrinkle from October 2018 to July 2019 in our hospital were received modified botulinum toxin type A injection. The 45 patients were treated with botulinum toxin type A (botox) with diluted concentration of 2U/0.1ml. A total of 8-15 points were injected on each side with 0.5U at each point. The clinical effect and complications were observed. Results 3-7d after injection， dynamic lateral canthus wrinkle disappeared in all patients， without bruising， diplopia， strabismus， smile asymmetry and other complications. The patients were satisfied with the effect. Conclusion Modified botulinum toxin type A injection technology has good effect on dynamic wrinkles in lateral canthus. This injection method has obvious curative effect and low side effect. It is an ideal injection method for wrinkles removal and worthy of clinical application.
Key words： botulinum toxin type A; lateral canthus wrinkle; modified injection; application effect; satisfaction; complication
外眥皱纹，俗称“鱼尾纹”，是人体衰老的表现之一，是指外眼角处的放射状皱纹，眼轮匝肌过度收缩是产生“鱼尾纹”的直接原因，年轻人主要表现为微笑时出现皱纹，静态时无皱纹，30岁以上的中老年人，动态性皱纹逐渐加深加重，并出现静态时深浅不等的皱纹[1]。近年来随着人们生活水平的提高和对美的追求，越来越多的患者想通过微创方法消除“鱼尾纹”。A型肉毒毒素是一种神经毒素，可抑制突出前膜释放乙酰胆碱，阻止神经递质的传递，进而抑制眼轮匝肌收缩达到去除动态性外眦皱纹的效果，安全可靠，操作方便，被广大医患群体所接受，本研究采用改良肉毒毒素注射技术去除外眦皱纹，现将临床研究报道如下。
1 资料和方法
1.1 一般资料：本次研究对象为2018年10月-2019年7月于笔者医院门诊接受外眦皱纹注射治疗的患者，共45例，90侧，其中男5例，女40例，年龄28～50岁，平均年龄(37±2.2)岁，其中有38例青年患者仅为外眦动态性皱纹，7例中老年患者外眦皮肤松垂并出现深浅不等的静态皱纹。患者均为身体健康，非妊娠或哺乳期，外眦部位无皮肤炎症或外伤，无面部肌肉运动障碍。注射前与患者充分沟通，告知注射可能产生的并发症，患者均表示理解并签署知情同意书。排除标准：①易过敏体质者;②精神明显异常或对治疗有不切实际的期望者;③合并心脑血管疾病者。, http://www.100md.com(杨媚 陈长永 林煌 李斌斌)
[关键性]A型肉毒毒素;外眦皱纹;改良技术;临床效果;满意度;并发症
[中图分类号]R622 [文献标志码]A [文章编号]1008-6455(2019)12-0011-03
Observation on the Effect of Modified Botulinum Toxin Type A Injection Technique in the Treatment of Lateral Canthus Wrinkles
YANG Mei，CHEN Chang-yong，LIN Huang，LI Bin-bin
(Department of Plastic Surgery and Laser，Beijing Anzhen Hospital Affiliated to Capital Medical University，Beijing 100029，China)
Abstract： Objective To observe the effect of modified botulinum toxin type A injection technique on lateral canthus wrinkle. Methods 45 cases with lateral canthus wrinkle from October 2018 to July 2019 in our hospital were received modified botulinum toxin type A injection. The 45 patients were treated with botulinum toxin type A (botox) with diluted concentration of 2U/0.1ml. A total of 8-15 points were injected on each side with 0.5U at each point. The clinical effect and complications were observed. Results 3-7d after injection， dynamic lateral canthus wrinkle disappeared in all patients， without bruising， diplopia， strabismus， smile asymmetry and other complications. The patients were satisfied with the effect. Conclusion Modified botulinum toxin type A injection technology has good effect on dynamic wrinkles in lateral canthus. This injection method has obvious curative effect and low side effect. It is an ideal injection method for wrinkles removal and worthy of clinical application.
Key words： botulinum toxin type A; lateral canthus wrinkle; modified injection; application effect; satisfaction; complication
外眥皱纹，俗称“鱼尾纹”，是人体衰老的表现之一，是指外眼角处的放射状皱纹，眼轮匝肌过度收缩是产生“鱼尾纹”的直接原因，年轻人主要表现为微笑时出现皱纹，静态时无皱纹，30岁以上的中老年人，动态性皱纹逐渐加深加重，并出现静态时深浅不等的皱纹[1]。近年来随着人们生活水平的提高和对美的追求，越来越多的患者想通过微创方法消除“鱼尾纹”。A型肉毒毒素是一种神经毒素，可抑制突出前膜释放乙酰胆碱，阻止神经递质的传递，进而抑制眼轮匝肌收缩达到去除动态性外眦皱纹的效果，安全可靠，操作方便，被广大医患群体所接受，本研究采用改良肉毒毒素注射技术去除外眦皱纹，现将临床研究报道如下。
1 资料和方法
1.1 一般资料：本次研究对象为2018年10月-2019年7月于笔者医院门诊接受外眦皱纹注射治疗的患者，共45例，90侧，其中男5例，女40例，年龄28～50岁，平均年龄(37±2.2)岁，其中有38例青年患者仅为外眦动态性皱纹，7例中老年患者外眦皮肤松垂并出现深浅不等的静态皱纹。患者均为身体健康，非妊娠或哺乳期，外眦部位无皮肤炎症或外伤，无面部肌肉运动障碍。注射前与患者充分沟通，告知注射可能产生的并发症，患者均表示理解并签署知情同意书。排除标准：①易过敏体质者;②精神明显异常或对治疗有不切实际的期望者;③合并心脑血管疾病者。, http://www.100md.com(杨媚 陈长永 林煌 李斌斌)