葛根素联合门冬胰岛素对妊娠期糖尿病孕妇生化指标及胎儿相关动脉血流参数的影响(1)
摘要目的：探討葛根素联合门冬胰岛素治疗妊娠期糖尿病孕妇血液生化指标及对胎儿脐动脉，肾动脉血流动力学指标的影响。方法：选取2014年12月至2016年12月郾城区人民医院收治的妊娠期糖尿病孕妇150例，随机分为门冬胰岛素单独对照组和葛根素联合门冬胰岛素观察组，每组75例。对照组给予门冬胰岛素治疗，联合观察组在门冬胰岛素基础上配合葛根素注射液治疗。比较2组临床疗效、空腹血糖(FBG)、2 h血糖值、糖化血红蛋白(HbA1c)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDLC)、胱抑素C(Cys C)、同型半胱氨酸(HCY)水平。运用彩色多普勒超声方法测定孕妇胎儿治疗前后脐动脉、肾动脉血流动力学指标变化。评估新生儿并发症发生率。结果：治疗后，2组的空腹血糖(FBG)、2 h血糖值、糖化血红蛋白(HbA1c)、总胆固醇(TC)、三酰甘油(TG)、胱抑素C(Cys C)、同型半胱氨酸(HCY)含量均较治疗前显著降低，其中观察组以上指标水平均显著低于对照组，差异有统计学意义(P<005)。观察组的HDLC水平显著高于对照组，差异有统计学意义(P<005)。与对照组比较，观察组脐动脉、肾动脉收缩期最大血流速度与舒张末期血流速度的比值(S/D)及阻力指数(RI)显著下降(P<005)。观察者新生儿并发症发生率与对照组比较显著降低(P<005)。结论：葛根素联合门冬胰岛素能够改善妊娠期糖尿病孕妇的血糖、血脂水平及降低脐动脉和肾动脉血流动力学指标，降低新生儿生长受限等并发症，科学起到保护孕妇和胎儿的作用，是理想的联合用药。
关键词葛根素；门冬胰岛素；妊娠期糖尿病；胎儿；血糖；血脂；血流动力学指标
Effects of Puerarin with Insulin Aspart on Biochemical Indexes and Artery Blood Flow Parameters
Related to the Fetus of Pregnant Women with Gestational Diabetes
Li Ling
(Department of Obstetrics and Gynecology， Yancheng District People′s Hospital， Luohe 462300， China)
AbstractObjective：To explore the effects of puerarin with insulin aspart on biochemical indexes and the fetus umbilical artery， renal artery blood flow mechanics index of pregnant women with gestational diabetes. Methods：A total of 150 cases of pregnant women with gestational diabetes in our hospital from December 2014 and December 2016 were selected and randomly divided into insulin aspart control group and puerarin with insulin aspart observation group， with 75 cases in each group. Control group was given insulin aspart therapy， and observation group was given insulin aspart with puerarin injection on the basis of insulin therapy. The clinical curative effect， fasting blood glucose (FBG)， glycosylated hemoglobin (HbA1c)， total cholesterol (TC)， three acyl glycerin (TG)， highdensity lipoprotein (HDLC)， cystatin (Cys C)， homocysteine (HCY) levels of two groups were compared. Color Doppler ultrasound method was used to determine fetus umbilical artery and renal arterial blood flow mechanics index changes before and after the treatment. The neonatal complications rat was assessed. Results：After treatment， fasting blood glucose (FBG)， 2 h blood sugar， glycosylated hemoglobin (HbA1c)， total cholesterol (TC)， three urinary inhibition acyl glycerin (TG)， Cys C and homocysteine (HCY) content of two groups were significantly reduced， and the above index level of observation group was significantly lower than the control group. The difference was statistically significant (P<005). HDLC of observation group was significantly higher than that of control group， and the difference was statistically significant (P<005). Compared with control group， umbilical artery， renal artery systolic blood flow velocity and the largest enddiastolic blood flow velocity ratio (S/D) and resistance index (RI) of the observation group was significantly decreased (P<005). Compared with the control group， the neonatal complications rate decreased significantly (P<005). Conclusion：The puerarin with insulin aspart can improve blood sugar， blood lipid levels in pregnant women who gestational diabetes and reduce the umbilical artery and renal artery blood flow mechanics index， reduce the neonatal complications such as growth restriction， and science and protect the pregnant women and fetus， which is the ideal combination., http://www.100md.com(李玲)
关键词葛根素；门冬胰岛素；妊娠期糖尿病；胎儿；血糖；血脂；血流动力学指标
Effects of Puerarin with Insulin Aspart on Biochemical Indexes and Artery Blood Flow Parameters
Related to the Fetus of Pregnant Women with Gestational Diabetes
Li Ling
(Department of Obstetrics and Gynecology， Yancheng District People′s Hospital， Luohe 462300， China)
AbstractObjective：To explore the effects of puerarin with insulin aspart on biochemical indexes and the fetus umbilical artery， renal artery blood flow mechanics index of pregnant women with gestational diabetes. Methods：A total of 150 cases of pregnant women with gestational diabetes in our hospital from December 2014 and December 2016 were selected and randomly divided into insulin aspart control group and puerarin with insulin aspart observation group， with 75 cases in each group. Control group was given insulin aspart therapy， and observation group was given insulin aspart with puerarin injection on the basis of insulin therapy. The clinical curative effect， fasting blood glucose (FBG)， glycosylated hemoglobin (HbA1c)， total cholesterol (TC)， three acyl glycerin (TG)， highdensity lipoprotein (HDLC)， cystatin (Cys C)， homocysteine (HCY) levels of two groups were compared. Color Doppler ultrasound method was used to determine fetus umbilical artery and renal arterial blood flow mechanics index changes before and after the treatment. The neonatal complications rat was assessed. Results：After treatment， fasting blood glucose (FBG)， 2 h blood sugar， glycosylated hemoglobin (HbA1c)， total cholesterol (TC)， three urinary inhibition acyl glycerin (TG)， Cys C and homocysteine (HCY) content of two groups were significantly reduced， and the above index level of observation group was significantly lower than the control group. The difference was statistically significant (P<005). HDLC of observation group was significantly higher than that of control group， and the difference was statistically significant (P<005). Compared with control group， umbilical artery， renal artery systolic blood flow velocity and the largest enddiastolic blood flow velocity ratio (S/D) and resistance index (RI) of the observation group was significantly decreased (P<005). Compared with the control group， the neonatal complications rate decreased significantly (P<005). Conclusion：The puerarin with insulin aspart can improve blood sugar， blood lipid levels in pregnant women who gestational diabetes and reduce the umbilical artery and renal artery blood flow mechanics index， reduce the neonatal complications such as growth restriction， and science and protect the pregnant women and fetus， which is the ideal combination., http://www.100md.com(李玲)
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