当归子饮对寻常型银屑病患者皮肤屏障功能及血流变的影响(1)

http://www.100md.com 2018年3月15日 《世界中医药》 20186

     摘要 目的：探討当归子饮对寻常型银屑病患者皮肤屏障功能及血流变的影响。方法：选取2015年8月至2017年7月广东省中西医结合医院收治的寻常型银屑病患者114例为研究对象，随机分为观察组和对照组，每组57例。2组均给予常规对症治疗，观察组在此基础上给予当归子饮治疗，4周为1个疗程，2组均连续治疗2个疗程。比较2组患者临床疗效，治疗前后皮肤屏障功能、血清炎性反应因子及血流变学指标。结果：治疗后观察组与对照组的总有效率分别为94.74%、80.70%，观察组显著高于对照组(P<0.05)；与治疗前比较，治疗后2组皮脂含量、角质层含水量均显著升高，且观察组显著高于对照组(P<0.01)；2组经表皮水分丢失量显著降低，且观察组显著低于对照组(P<0.01)；与治疗前比较，治疗后2组血清IL-2、IL-8、IFN-γ水平均显著下降(P<0.01)，且观察组显著低于对照组(P<0.05或P<0.01)；2组血清IL-4水平均显著升高，且观察组显著高于对照组(P<0.01)；与治疗前比较，治疗后2组高/中/低切全血黏度、血浆黏度、红细胞比容等均显著下降(P<0.05或P<0.01)，且观察组显著低于对照组(P<0.01)。结论：当归子饮可有效改善寻常型银屑病患者皮肤屏障功能，降低血清炎性反应因子水平，促进血流变学恢复正常，临床疗效优于单用常规西药。
, 百拇医药
    关键词 当归子饮；寻常型银屑病；皮肤屏障功能；血流变

    AbstractObjective：Toexploretheeffectofdangguiziyinonskinbarrierfunctionandhemorheologyofpatientswithpsoriasisvulgaris.Methods：Atotalof114casesofpatientswithpsoriasisvulgarisinourhospitalwereselectedastheresearchobjects，andwererandomlydividedintotheobservationgroupandthecontrolgroup，witheachgroupfor57cases.2groupsweregivenroutinesymptomatictreatment.Theobservationgroupwastreatedwiththedangguiziyinonthebasisofthat，4weeksfor1course，and2groupsweretreatedcontinuouslyfor2courses.Theclinicalefficacyof2groups，theskinbarrierfunction，seruminflammatoryfactorsandhemorheologicalindexesbeforeandaftertreatmentwerecompared.Results：Thetotaleffectiveratesoftheobservationgroupandthecontrolgroupwererespectively94.74%，80.70%.Theobservationgroupwassignificantlyhigherthanthecontrolgroup(P<0.05).Comparedwiththosebeforetreatment，thesebumcontentandcuticlemoisturecontentof2groupssignificantlyincreasedaftertreatment，andtheobservationgroupwassignificantlyhigherthanthecontrolgroup(P<0.01).Thewaterlossthroughtheepidermissignificantlyreduced，andtheobservationgroupwassignificantlylowerthanthecontrolgroup(P<0.01).Comparedwiththosebeforetreatment，theserumIL-2，IL-8，IFN-γlevlesof2groupsaftertreatmentsignificantlydecreased，andtheobservationgroupwassignificantlylowerthanthecontrolgroup(P<0.05orP<0.01).TheserumIL-4levelof2groupssignificantlyincreased，andtheobservationgroupwassignificantlyhigherthanthecontrolgroup(P<0.01).Comparedthosewithbeforetreatment，thehigh/medium/lowshearwholebloodviscosity，plasmaviscosityandhematocritof2groupsaftertreatmentsignificantlydecreased(P<0.05orP<0.01)，andtheobservationgroupwassignificantlylowerthanthecontrolgroup(P<0.01).Conclusion：Dangguiziyincaneffectivelyimproveskinbarrierfunctionofpatientswithpsoriasisvulgaris，reducetheseruminflammatoryfactorslevels，promotethehemorheologyreturntonormal.Andtheclinicaleffectisbetterthanconventionalwesternmedicinealone., http://www.100md.com(林锐辉 莫怀民)

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