活血化瘀法与氨基葡萄糖胶囊治疗创伤性膝骨性关节炎基质金属蛋白酶表达的影响(4)
本研究分别使用了2种方法来治疗创伤性膝骨关节炎,结果发现口服盐酸氨基葡萄糖胶囊和口服活血化瘀协定方汤剂均能有效的缓解患者的临床症状,并且这种治疗效果可能是归因于药物对关节液和血清中MMP的抑制效果。活血化瘀中药法总有效率高于盐酸氨基葡萄糖胶囊,可能是由于活血化瘀中药汤剂中复杂的中草药成分能够有效的抑制MMP1和MMP3的蛋白表达量,而盐酸氨基葡萄糖胶囊只能单一的抑制MMP3的蛋白表达量,从而有效的降低对软骨的破坏作用,缓解疾病的进程。
参考文献
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[11]Troeberg L,Nagase H.Proteases involved in cartilage matrix degradation in osteoarthritis[J].Biochim Biophys Acta,2012,1824(1):133-45.
[12]Nagase H.Activation mechanisms of matrix metalloproteinases[J].Biol Chem,1997,378(3-4):151-160.
[13]Lugo JP,Saiyed ZM,Lane NE.Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms:a multicenter randomized,double-blind,placebo-controlled study[J].Nutr J,2016,15:14.
[14]王平,古恩鹏,曹闳喻.活血化瘀膏对早中期膝骨性关节炎关节液NO和MMP-13的影响研究[J].天津中医药,2010,, http://www.100md.com(陈明光 陈仕强 杨宁 杨进 李引刚 曹晓霞 常春峰 吴雪兰)
参考文献
[1] Loeser RF,Goldring SR,Scanzello CR,et al.Osteoarthritis:a disease of the joint as an organ[J].Arthritis Rheum,2012,64(6):1697-1707.
[2]Buckwalter JA,Brown TD.Joint injury,repair,and remodeling:roles in post-traumatic osteoarthritis[J].Clin Orthop Relat Res,2004,(423):7-16.
[3]Little CB,Hunter DJ.Post-traumatic osteoarthritis:from mouse models to clinical trials[J].Nat Rev Rheumatol,2013,9(8):485-497.
[4] Brown TD,Johnston RC,Saltzman CL,et al.Posttraumatic osteoarthritis:a first estimate of incidence,prevalence,and burden of disease[J].J Orthop Trauma,2006,20(10):739-744.
[5]Jordan JM,Linder GF,Renner JB,et al.The impact of arthritis in rural populations[J].Arthritis Care Res,1995,8(4):242-250.
[6]Shen CL,Smith BJ,Lo DF,et al.Dietary polyphenols and mechanisms of osteoarthritis[J].J Nutr Biochem,2012,23(11):1367-1377.
[7]Haseeb A,Haqqi TM.Immunopathogenesis of osteoarthritis[J].Clin Immunol,2013,146(3):185-196.
[8]Natoli RM,Scott CC,Athanasiou KA.Temporal effects of impact on articular cartilage cell death,gene expression,matrix biochemistry,and biomechanics[J].Ann Biomed Eng,2008,36(5):780-792.
[9]蘇雅红.活血化瘀法加补肾法治疗膝关节性关节的临床研究[C].泛中医论坛,思考中医——经典中医的特色和优势,南宁.2006:7.
[10] 邱建文,王禹燕,麦少云,等.针灸治疗膝关节骨性关节炎45例临床观察[J].中医药导报,2012,18(12):62-64.
[11]Troeberg L,Nagase H.Proteases involved in cartilage matrix degradation in osteoarthritis[J].Biochim Biophys Acta,2012,1824(1):133-45.
[12]Nagase H.Activation mechanisms of matrix metalloproteinases[J].Biol Chem,1997,378(3-4):151-160.
[13]Lugo JP,Saiyed ZM,Lane NE.Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms:a multicenter randomized,double-blind,placebo-controlled study[J].Nutr J,2016,15:14.
[14]王平,古恩鹏,曹闳喻.活血化瘀膏对早中期膝骨性关节炎关节液NO和MMP-13的影响研究[J].天津中医药,2010,, http://www.100md.com(陈明光 陈仕强 杨宁 杨进 李引刚 曹晓霞 常春峰 吴雪兰)