空腹血糖受损与糖耐量受损者胰岛素抵抗及胰岛B细胞功能的比较(1)
【摘要】 目的 比较空腹血糖受损(IFG)与糖耐量受损者(IGT)胰岛素抵抗及胰岛B细胞功能的不同。方法 参照2003 年ADA 专家委员会建议标准,选择正常糖耐量者(NGT)51例,空腹血糖受损者30例,糖耐量受损者27例。测身高、体质量、血压、血脂及OGTT5点血糖值及胰岛素值。采用HOMA-IR 评价IR , HBCI、△I30/△G30、MBCI分别评价基础状态下及糖负荷后的胰岛素分泌功能。结果 校正年龄、性别、BMI后，IFG、IGT组HOMA-IR均明显高于NGT人群，差异有统计学意义(P30/△G30与IFG组比较有下降, 但差异无统计学意义。结论 空腹血糖受损人群与糖耐量受损人群均存在明显胰岛素抵抗,空腹血糖受损人群主要表现为基础胰岛素分泌缺陷, 而糖耐量受损人群为胰岛素早期分泌受损。
【关键词】 空腹血糖受损; 糖耐量受损; 胰岛素抵抗; 胰岛B细胞功能。
, 百拇医药 Study of the function of islet Bcell and insulin resistance in cases with impaired fasting glucose and impaired glucose tolerance XIA Jing. Shandong Rong Jun General Hospital, Jinan,250013，China
【Abstract】 Objective To compare the difference of islet B cell function and insulin resistance between impaired fasting glucose and impaired glucose tolerance. Methods51 patients with normal glucose tolerance,30 with impaired fasting glucose and 27 with impaired glucose tolerance were measured their levels of body mass index, blood pressure, lipids,plasma glucose and insulin after OGTT. Insulin secretion and insulin resistance were evaluated and the following indexes were calculated: early insulin secretion index(△I30/△G30); HOMA-B cell index(HBCI) of HOMA model; HOMA-IR; Dr. Li’s new B-cell insulin secretion index(MBCI). ResultsAfter age, sex and BMI adjustment, HOMA-IR in IFG and IGT group obviously increased(P30/△G30 between IFG and IGT groups. ConclusionIFG and IGT groups have significant IR. The individuals with IFG mainly showed defect of basic B cell function , the subjects with IGT showed defect of the early phase of insulin secretion.
, 百拇医药
【Key words】 Impaired fasting glucose; Impaired glucose tolerance; Insulin resistance; Islet B cell function
空腹血糖受损(IFG)与糖耐量受损(IGT)都是介于正常糖耐量(NGT)与糖尿病之间的中间代谢状态，都是糖尿病的危险因素，是发生心血管病的危险标志[1]。胰岛素抵抗(IR)与胰岛B细胞功能异常是引起IGT和IFG的共同因素[2]。但关于IFG胰岛B细胞功能及胰岛素抵抗的研究报道结果并不一致,我们对此进行了研究,并与IGT 患者进行比较。
1 资料与方法
1.1 临床资料 选择2006年我院健康查体人群108例作为研究对象。男64例、女44例，年龄24～74岁、平均46.8岁。根据2003 年ADA 专家委员会建议的诊断标准，分为3组，NGT组[空腹血糖(FPG)30/△G30) = (Ins30-Ins0)/(G30- G0)[3]作为负荷后早期胰岛功能评价指标。李氏B细胞功能指数(MBCI)=(FIns×FPG)/(PG2 h+PG1h-2FPG)[4]为糖负荷后胰岛功能评价指标。, http://www.100md.com(夏 靖)
【关键词】 空腹血糖受损; 糖耐量受损; 胰岛素抵抗; 胰岛B细胞功能。
, 百拇医药 Study of the function of islet Bcell and insulin resistance in cases with impaired fasting glucose and impaired glucose tolerance XIA Jing. Shandong Rong Jun General Hospital, Jinan,250013，China
【Abstract】 Objective To compare the difference of islet B cell function and insulin resistance between impaired fasting glucose and impaired glucose tolerance. Methods51 patients with normal glucose tolerance,30 with impaired fasting glucose and 27 with impaired glucose tolerance were measured their levels of body mass index, blood pressure, lipids,plasma glucose and insulin after OGTT. Insulin secretion and insulin resistance were evaluated and the following indexes were calculated: early insulin secretion index(△I30/△G30); HOMA-B cell index(HBCI) of HOMA model; HOMA-IR; Dr. Li’s new B-cell insulin secretion index(MBCI). ResultsAfter age, sex and BMI adjustment, HOMA-IR in IFG and IGT group obviously increased(P30/△G30 between IFG and IGT groups. ConclusionIFG and IGT groups have significant IR. The individuals with IFG mainly showed defect of basic B cell function , the subjects with IGT showed defect of the early phase of insulin secretion.
, 百拇医药
【Key words】 Impaired fasting glucose; Impaired glucose tolerance; Insulin resistance; Islet B cell function
空腹血糖受损(IFG)与糖耐量受损(IGT)都是介于正常糖耐量(NGT)与糖尿病之间的中间代谢状态，都是糖尿病的危险因素，是发生心血管病的危险标志[1]。胰岛素抵抗(IR)与胰岛B细胞功能异常是引起IGT和IFG的共同因素[2]。但关于IFG胰岛B细胞功能及胰岛素抵抗的研究报道结果并不一致,我们对此进行了研究,并与IGT 患者进行比较。
1 资料与方法
1.1 临床资料 选择2006年我院健康查体人群108例作为研究对象。男64例、女44例，年龄24～74岁、平均46.8岁。根据2003 年ADA 专家委员会建议的诊断标准，分为3组，NGT组[空腹血糖(FPG)30/△G30) = (Ins30-Ins0)/(G30- G0)[3]作为负荷后早期胰岛功能评价指标。李氏B细胞功能指数(MBCI)=(FIns×FPG)/(PG2 h+PG1h-2FPG)[4]为糖负荷后胰岛功能评价指标。, http://www.100md.com(夏 靖)