介入栓塞治疗肝血管瘤57例临床研究(1)
【摘要】 目的 分析和探讨平阳霉素碘化油乳剂(PLE)超选择肝段动脉栓塞在肝血管瘤介入治疗中的临床疗效。方法 57例肝血管瘤患者进行超选择动脉栓塞治疗， 其中41例运用 PLE联合聚乙烯醇颗粒进行栓塞治疗作为B组， 16例选用超液态碘化油(LE)、适量造影剂联合聚乙烯醇颗粒制成乳剂进行栓塞作为A组， 术后 3～12个月观察碘油沉积、肿瘤大小变化及并发症的发生情况。结果 所有患者术前肝动脉造影显示供血动脉轻度增粗， 瘤体较大时可有受压移位征象。动脉早期血窦显影， 血窦染色常维持到肝实质后期， 持续不退， 为“早出晚归”表现。栓塞后肿瘤内碘油沉积良好， 造影复查血管瘤染色缺如， 供血血管消失。两组患者第1次栓塞后 12 个月复查疗效比较， 差异具有统计学意义(P<0.05)。结论 平阳霉素碘化油乳剂联合聚乙烯醇颗粒动脉栓塞治疗肝血管瘤是一种疗效肯定、安全理想的治疗方法。
【关键词】 肝血管瘤；平阳霉素；栓塞；碘化油
DOI：10.14163/j.cnki.11-5547/r.2015.14.002
, http://www.100md.com
Clinical analysis of interventional embolization in the treatment of 57 hepatic hemangioma cases ZHU Hai-tao， LI Xiao-guang， MA Qiang， et al. Department of Intervention， Shandong Zoucheng City People’s Hospital， Zoucheng 273500， China
【Abstract】 Objective To analyze and investigate the clinical effect by Pingyangmycin lipiodol emulsion (PLE) super choice hepatic artery embolization in interventional treatment of hepatic hemangioma. Methods Super choice hepatic artery embolization treatment was applied for 57 hepatic hemangioma patients. 41 case among them as group B received PLE combined with polyvinyl alcohol granule for embolization treatment， and the other 16 cases as group A received LE， contrast medium combined with polyvinyl alcohol granule for mixed emulsion in embolization treatment. In 3～12 months after operation， deposition of lipiodol， changes of tumor size and complications condition were observed. Results All the patients had mild thickening in feeding artery shown by preoperative hepatic angiography， and they might have compression displacement signs due to big tumor size. Early artery blood sinus angiography showed that blood sinus dye lasted till late stage of liver parenchyma， with the manifestation of “early leave and late return”. After embolization， deposition of lipiodol in tumor was good. Angiography reexamination showed absence of hemangioma dye and disappearance of feeding artery. Comparison between curative effects between the two groups in 12 months after operation showed a statistically significant difference (P<0.05). Conclusion Combination of Pingyangmycin lipiodol emulsion and polyvinyl alcohol granule is an ideal treatment method with precise effect in treating hepatic hemangioma by embolization.
【Key words】 Hepatic hemangioma； Pingyangmycin； Embolization； Lipiodol
肝动脉栓塞治疗肝海绵状血管瘤(hepatic cavernous hemangioma)， 以前报道多数采用无水酒精、明胶海绵颗粒及聚乙烯醇(PVA)作为栓塞剂[1-4]。平阳霉素为国产抗肿瘤抗生素， 临床应用发现其对血管内皮细胞有抑制和破坏作用[5]。作者对本院57例肝血管瘤患者进行动脉栓塞治疗对照分析， 采用平阳霉素碘化油乳剂(pingyangmycin lipiodol emulsion， PLE)对41例肝海绵状血管瘤行血管内栓塞治疗取得了较好疗效， 现报告如下。, 百拇医药(朱海涛 李晓光 马强 李振峰)
【关键词】 肝血管瘤；平阳霉素；栓塞；碘化油
DOI：10.14163/j.cnki.11-5547/r.2015.14.002
, http://www.100md.com
Clinical analysis of interventional embolization in the treatment of 57 hepatic hemangioma cases ZHU Hai-tao， LI Xiao-guang， MA Qiang， et al. Department of Intervention， Shandong Zoucheng City People’s Hospital， Zoucheng 273500， China
【Abstract】 Objective To analyze and investigate the clinical effect by Pingyangmycin lipiodol emulsion (PLE) super choice hepatic artery embolization in interventional treatment of hepatic hemangioma. Methods Super choice hepatic artery embolization treatment was applied for 57 hepatic hemangioma patients. 41 case among them as group B received PLE combined with polyvinyl alcohol granule for embolization treatment， and the other 16 cases as group A received LE， contrast medium combined with polyvinyl alcohol granule for mixed emulsion in embolization treatment. In 3～12 months after operation， deposition of lipiodol， changes of tumor size and complications condition were observed. Results All the patients had mild thickening in feeding artery shown by preoperative hepatic angiography， and they might have compression displacement signs due to big tumor size. Early artery blood sinus angiography showed that blood sinus dye lasted till late stage of liver parenchyma， with the manifestation of “early leave and late return”. After embolization， deposition of lipiodol in tumor was good. Angiography reexamination showed absence of hemangioma dye and disappearance of feeding artery. Comparison between curative effects between the two groups in 12 months after operation showed a statistically significant difference (P<0.05). Conclusion Combination of Pingyangmycin lipiodol emulsion and polyvinyl alcohol granule is an ideal treatment method with precise effect in treating hepatic hemangioma by embolization.
【Key words】 Hepatic hemangioma； Pingyangmycin； Embolization； Lipiodol
肝动脉栓塞治疗肝海绵状血管瘤(hepatic cavernous hemangioma)， 以前报道多数采用无水酒精、明胶海绵颗粒及聚乙烯醇(PVA)作为栓塞剂[1-4]。平阳霉素为国产抗肿瘤抗生素， 临床应用发现其对血管内皮细胞有抑制和破坏作用[5]。作者对本院57例肝血管瘤患者进行动脉栓塞治疗对照分析， 采用平阳霉素碘化油乳剂(pingyangmycin lipiodol emulsion， PLE)对41例肝海绵状血管瘤行血管内栓塞治疗取得了较好疗效， 现报告如下。, 百拇医药(朱海涛 李晓光 马强 李振峰)