老年原发性肝癌患者临床病理特点及预后观察(1)
【摘要】 目的 对患有原发性肝癌的老年患者的临床病理特征及预后特点进行观察分析。方法 147例原发性肝癌老年患者， 随机分为手术治疗组50例、介入治疗组49例和保守治疗组18例。对其临床特征如：肿瘤大小、治疗措施、性别、年龄等进行观察并总结分析。结果 介入治疗组患者1、2、5年的生存率为71.43%、55.10%、10.20%；保守治疗组患者分别为14.58%、6.25%、0；手术治疗组分别为82.00%、64.00%、24.00%。手术治疗组患者的生存率最高， 介入治疗组患者的生存率要显著高于保守治疗组患者， 差异有统计学意义(P<0.05)。结论 老年原发性肝癌发病的主要原因是肝炎病毒感染。介入治疗能够有效提高患者的生存率， 手术治疗也可以取得不错成效。
【关键词】 老年；原发性肝癌；预后观察
DOI：10.14163/j.cnki.11-5547/r.2015.27.010
Clinical pathological characteristics and prognosis observation in senile patients with primary carcinoma of liver JIN Chun-xue. Department of Pathology， Jilin Songyuan City Central Hospital， Songyuan 138000， China
, 百拇医药
【Abstract】 Objective To observe and analyze clinical pathological characteristics and prognosis observation in senile patients with primary carcinoma of liver. Methods A total of 147 senile patients with primary carcinoma of liver in same period were randomly divided into surgical treatment group with 50 cases， intervention treatment group with 49 cases and conservative treatment group with 48 cases. Observation， summary and analysis were made on their clinical characteristics， such as tumor size， treatment measures， gender， and age. Results The intervention treatment group had 1， 2， 5 years survival rates as 71.43%， 55.10% and 10.20%. These rates in the conservative treatment group were 14.58%， 6.25% and 0. The surgical treatment group had the rates as 82.00%， 64.00% and 24.00%. The surgical treatment group had the highest survival rate， and the intervention treatment group had much higher survival rate than the conservative treatment group. Their difference had statistical significance (P<0.05). Conclusion Main pathogenesis of senile primary carcinoma of liver is hepatitis virus infection. Implement of intervention treatment can effectively improve survival rate in patients， and surgical treatment contains good effects as well.
, 百拇医药
【Key words】 Senile； Primary carcinoma of liver； Prognosis observation
原发性肝癌(primary carcinoma of liver)是指由肝细胞或肝内胆管细胞发生的癌肿。临床上以肝细胞肝癌最多见。肝癌是世界上最常见的恶性肿瘤之一。我国的肝癌患者约占全世界的50%。其病死率高， 在恶性肿瘤死亡顺位中仅次于胃、食道而居第三位。近年来， 依靠血清甲胎蛋白(AFP)检测结合超声检查， 使肝癌在亚临床阶段即作出诊断， 早期手术治疗加之积极综合治疗， 使5年生存率显著提高。本病可发生任何年龄， 以40～49岁最多， 男女之比为2.5∶1。老年人为低发生率人群， 最多发生在60多岁， 平均55～62岁。常见于我国临床， 据流行病调查报告显示， 原发性肝癌年死亡率居恶性肿瘤的年死亡率第二。此次研究通过对老年原发性肝癌患者的临床资料进行回顾性分析， 总结原发性肝癌的临床特点及影响预后质量的因素， 从而探讨老年原发性肝癌优秀的治疗措施。现报告如下。
1 资料与方法
1. 1 一般资料 选取2007～2010年于本院进行原发性肝癌治疗的老年患者147例， 将其作为研究对象并根据患者的治疗措施分为手术治疗组50例、介入治疗组49例和保守治疗组48例。选取的147例患者中， 140例(95.24%)患者曾感染过肝炎病毒， 93例(63.27%)患者(曾)患有慢性肝炎， 83例(56.46%)患者合并患有肝纤维化或肝硬化。其中男92例， 女55例；年龄66～87岁， 平均年龄(68.32±6.31)岁， 所有患者均经过血液生化、肝组织学及影像检查确诊患有原发性肝癌。三组一般资料比较差异无统计学意义(P>0.05)， 具有可比性。, 百拇医药(金春雪)
【关键词】 老年；原发性肝癌；预后观察
DOI：10.14163/j.cnki.11-5547/r.2015.27.010
Clinical pathological characteristics and prognosis observation in senile patients with primary carcinoma of liver JIN Chun-xue. Department of Pathology， Jilin Songyuan City Central Hospital， Songyuan 138000， China
, 百拇医药
【Abstract】 Objective To observe and analyze clinical pathological characteristics and prognosis observation in senile patients with primary carcinoma of liver. Methods A total of 147 senile patients with primary carcinoma of liver in same period were randomly divided into surgical treatment group with 50 cases， intervention treatment group with 49 cases and conservative treatment group with 48 cases. Observation， summary and analysis were made on their clinical characteristics， such as tumor size， treatment measures， gender， and age. Results The intervention treatment group had 1， 2， 5 years survival rates as 71.43%， 55.10% and 10.20%. These rates in the conservative treatment group were 14.58%， 6.25% and 0. The surgical treatment group had the rates as 82.00%， 64.00% and 24.00%. The surgical treatment group had the highest survival rate， and the intervention treatment group had much higher survival rate than the conservative treatment group. Their difference had statistical significance (P<0.05). Conclusion Main pathogenesis of senile primary carcinoma of liver is hepatitis virus infection. Implement of intervention treatment can effectively improve survival rate in patients， and surgical treatment contains good effects as well.
, 百拇医药
【Key words】 Senile； Primary carcinoma of liver； Prognosis observation
原发性肝癌(primary carcinoma of liver)是指由肝细胞或肝内胆管细胞发生的癌肿。临床上以肝细胞肝癌最多见。肝癌是世界上最常见的恶性肿瘤之一。我国的肝癌患者约占全世界的50%。其病死率高， 在恶性肿瘤死亡顺位中仅次于胃、食道而居第三位。近年来， 依靠血清甲胎蛋白(AFP)检测结合超声检查， 使肝癌在亚临床阶段即作出诊断， 早期手术治疗加之积极综合治疗， 使5年生存率显著提高。本病可发生任何年龄， 以40～49岁最多， 男女之比为2.5∶1。老年人为低发生率人群， 最多发生在60多岁， 平均55～62岁。常见于我国临床， 据流行病调查报告显示， 原发性肝癌年死亡率居恶性肿瘤的年死亡率第二。此次研究通过对老年原发性肝癌患者的临床资料进行回顾性分析， 总结原发性肝癌的临床特点及影响预后质量的因素， 从而探讨老年原发性肝癌优秀的治疗措施。现报告如下。
1 资料与方法
1. 1 一般资料 选取2007～2010年于本院进行原发性肝癌治疗的老年患者147例， 将其作为研究对象并根据患者的治疗措施分为手术治疗组50例、介入治疗组49例和保守治疗组48例。选取的147例患者中， 140例(95.24%)患者曾感染过肝炎病毒， 93例(63.27%)患者(曾)患有慢性肝炎， 83例(56.46%)患者合并患有肝纤维化或肝硬化。其中男92例， 女55例；年龄66～87岁， 平均年龄(68.32±6.31)岁， 所有患者均经过血液生化、肝组织学及影像检查确诊患有原发性肝癌。三组一般资料比较差异无统计学意义(P>0.05)， 具有可比性。, 百拇医药(金春雪)