【摘要】 目的 对比分析枸橼酸咖啡因与氨茶碱治疗早产儿原发性呼吸暂停的临床疗效和安全性。方法 122例早产儿原发性呼吸暂停患儿， 随机分为观察组(给予枸橼酸咖啡因治疗)和对照组(给予氨茶碱治疗)， 各61例。比较两组的治疗效果和不良反应发生情况。结果 观察组用药后3 d内呼吸暂停发生次数(12.82±2.87)次少于对照组的(14.21±2.66)次， 用药时间(14.41±3.85)d短于对照组的(17.12±4.61)d(P<0.05)。观察组消化功能紊乱、高血糖发生率(8.2%、4.9%)低于对照组(21.3%、18.0%)(P<0.05)。结论 枸橼酸咖啡因治疗早产儿原发性呼吸暂停， 疗效优于氨茶碱， 不良反应发生率更低。

    【关键词】 枸橼酸咖啡因；氨茶碱；早产儿原发性呼吸暂停

    DOI：10.14163/j.cnki.11-5547/r.2016.27.001

    【Abstract】 Objective To compare and analyze clinical effect and safety by caffeine citrate and aminophylline in the treatment of primary apnea of prematurity. Methods A total of 122 infants with primary apnea of prematurity were randomly divided into observation group (received caffeine citrate for treatment) and control group (received aminophylline for treatment) ......