返流性食管炎与精神因素的关系分析(1)
【摘要】 目的 分析返流性食管炎(RE)与精神因素的关联性。方法 102例返流性食管炎患者经过焦虑与抑郁评价系统评定后有78例患者评分异常， 采取计算机随机分组方案分为常规组及实验组， 每组39例。常规组给予奥美拉唑治疗， 实验组在常规组基础上加用帕罗西汀治疗。对比两组治疗后心理症状评分、临床症状积分变化情况、药物不良反应。结果 实验组患者的躯体化、强迫症状、焦虑、抑郁心理症状评分低于常规组， 差异均具有统计学意义 (P<0.05) ；两组患者的人际关系敏感、敌对、恐怖、偏执、精神病性心理症状评分比较， 差异均无统计学意义(P>0.05)。实验组患者临床症状积分为(0.90±0.43)分， 低于常规组的(1.23±0.42)分， 差异具有统计学意义 (P<0.05)。两组患者均未出现较为严重的药物不良反应。结论 返流性食管炎与精神因素具有十分紧密的关联性， 临床上应及时进行积极治疗， 帮助患者提高治疗效果， 缓解不良情绪。
【关键词】 精神因素；返流性食管炎；分析
DOI：10.14163/j.cnki.11-5547/r.2017.17.010
Correlation analysis between reflux esophagitis and mental factor CHEN Rong-guo， HE Min， LI Zhi-jian， et al. Guangdong Dongguan City People’s Hospital， Dongguan 523000， China
【Abstract】 Objective To analyze the correlation between reflux esophagitis (RE) and mental factor. Methods There were 78 patients with abnormal scores by evaluation system of anxiety and depression in 102 reflux esophagitis patients， and they were divided by computer random grouping scheme into conventional group and experimental group， with 39 cases in each group. The conventional group received omeprazole for treatment， and the experimental group also received paroxetine for treatment. Comparison were made on change of mental symptom scores and clinical symptoms integral， and adverse drug reactions after treatment in two groups. Results The experimental group had lower mental symptom scores of somatization， forced symptoms， anxiety， depression than the conventional group， and their difference had statistical significance (P<0.05). Both groups had no statistically significant difference in mental symptom scores of interpersonal sensitivity， hostility， terror， paranoia， psychosis (P>0.05). The experimental group had lower clinical symptom integral as (0.90±0.43) points than (1.23±0.42) points in the conventional group， and the difference had statistical significance (P<0.05). Both groups had no serious adverse drug reactions. Conclusion Reflux esophagitis and mental factors have very close correlation， active treatment should be performed in clinic to help patients improve the treatment effect and reduce bad feelings.
【Key words】 Mental factor； Reflux esophagitis； Analysis
返流性食管炎在臨床上较为多见， 属于一类消化系统疾病[1]， 近些年来该类疾病的发病率逐年递增， 并对患者的日常生活质量造成了严重的影响， 有研究显示出现返流性食管炎的因素较为复杂， 包括心理、社会等多种因素[2]， 并逐渐受到医学界的广泛重视。为此， 本次研究旨在分析返流性食管炎与精神因素的关联性， 并采取积极的临床治疗， 详情见下文。
1 资料与方法
1. 1 一般资料 选择2015年1月～2016年3月至本院就诊的返流性食管炎患者102例， 所有患者均经临床常规诊断后显示疾病被确诊， 对本次实验均知情同意， 同时将胃肠道肿瘤、消化性溃疡、硬皮病、糖尿病、神经系统疾病、继发性返流性食管炎患者排除。102例患者中男54例， 女48例， 年龄22～68岁， 平均年龄(45.63±7.46)岁。102例返流性食管炎患者经过焦虑与抑郁评价系统评定后有78例患者评分异常， 采取计算机随机分组方案分为常规组及实验组， 每组39例。, http://www.100md.com(陈荣国 何敏 李志坚 黄妙兴 李笑青)
【关键词】 精神因素；返流性食管炎；分析
DOI：10.14163/j.cnki.11-5547/r.2017.17.010
Correlation analysis between reflux esophagitis and mental factor CHEN Rong-guo， HE Min， LI Zhi-jian， et al. Guangdong Dongguan City People’s Hospital， Dongguan 523000， China
【Abstract】 Objective To analyze the correlation between reflux esophagitis (RE) and mental factor. Methods There were 78 patients with abnormal scores by evaluation system of anxiety and depression in 102 reflux esophagitis patients， and they were divided by computer random grouping scheme into conventional group and experimental group， with 39 cases in each group. The conventional group received omeprazole for treatment， and the experimental group also received paroxetine for treatment. Comparison were made on change of mental symptom scores and clinical symptoms integral， and adverse drug reactions after treatment in two groups. Results The experimental group had lower mental symptom scores of somatization， forced symptoms， anxiety， depression than the conventional group， and their difference had statistical significance (P<0.05). Both groups had no statistically significant difference in mental symptom scores of interpersonal sensitivity， hostility， terror， paranoia， psychosis (P>0.05). The experimental group had lower clinical symptom integral as (0.90±0.43) points than (1.23±0.42) points in the conventional group， and the difference had statistical significance (P<0.05). Both groups had no serious adverse drug reactions. Conclusion Reflux esophagitis and mental factors have very close correlation， active treatment should be performed in clinic to help patients improve the treatment effect and reduce bad feelings.
【Key words】 Mental factor； Reflux esophagitis； Analysis
返流性食管炎在臨床上较为多见， 属于一类消化系统疾病[1]， 近些年来该类疾病的发病率逐年递增， 并对患者的日常生活质量造成了严重的影响， 有研究显示出现返流性食管炎的因素较为复杂， 包括心理、社会等多种因素[2]， 并逐渐受到医学界的广泛重视。为此， 本次研究旨在分析返流性食管炎与精神因素的关联性， 并采取积极的临床治疗， 详情见下文。
1 资料与方法
1. 1 一般资料 选择2015年1月～2016年3月至本院就诊的返流性食管炎患者102例， 所有患者均经临床常规诊断后显示疾病被确诊， 对本次实验均知情同意， 同时将胃肠道肿瘤、消化性溃疡、硬皮病、糖尿病、神经系统疾病、继发性返流性食管炎患者排除。102例患者中男54例， 女48例， 年龄22～68岁， 平均年龄(45.63±7.46)岁。102例返流性食管炎患者经过焦虑与抑郁评价系统评定后有78例患者评分异常， 采取计算机随机分组方案分为常规组及实验组， 每组39例。, http://www.100md.com(陈荣国 何敏 李志坚 黄妙兴 李笑青)