小剂量米非司酮治疗围绝经期功能失调性子宫出血效果观察(1)
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[摘要] 目的:探讨小剂量米非司酮治疗围绝经期功能失调性子宫出血(功血)的临床效果。方法:选择2007年3月～2008年12月营口市鲅鱼圈区疾病控制及妇幼保健中心确诊的围绝经期功血24例患者,采用米非司酮治疗(每片25 g),每晚服米非司酮片12.5 g,连续3个月,观察治疗效果。结果:B超监测24例患者服药前子宫内膜1.1～2.1 cm,服药1个月内膜厚0.6～1.0 cm,服药2个月内膜厚0.3～0.7 cm,服药3个月为线状内膜。服药前后子宫内膜厚度比较,差异有统计学意义(P<0.05)。24例患者服药期间均闭经,停止治疗后3～6周月经恢复正常。结论:对围绝经期功血采用小剂量米非司酮治疗,是一种比较安全有效的方法,值得临床推广。
[关键词] 米非司酮;围绝经期功血
[中图分类号]R711.52 [文献标识码]B [文章编号]1673-7210(2010)04(c)-044-02
Clinical analysis of mifepristone in treatment of patients with perimenopause dysfunctional uterine bleeding
DONG Zhenhuan,SONG Zhaohui
(1.Center for Women and Children's Health,center for Disease Control in Bayuquan district of Yingkou City,Yingkou 115007, China;2.The Obstrics and gynaecology and Children Hospital of Yingkou City,Yingkou 115001, China)
[Abstract] Objective: To study the therapeutical effect of low-dose mifepristone on peripheral menopause syndrome. Methods: 24 cases with perimenopausal dysfunctional uterine bleeding were selected from patients treated in center for Women and Children's Health in Bayuquan district,Yingkou City from March 2007 to December 2008. Mifepristone tablets were taken 12.5 g every night for 3 months.Then observed the therapeutic effect. Results: B-ultrasonic examination showed that before treatment endometrial thickness of 24 patients was 1.1-2.1 cm,within 1 month treatment 0.6-1.0 cm,within 2 months treatment was 0.3-0.7 cm.After 3 months treatment,they had thin endometrium. Statistically significant difference could be found between before and after treatment endometrial thickness(P<0.05). During treatment 24 patients were amenorrhea. Menstruation would be abnormal for 3-6 weeks after treatment. Conclusion: Treatmentment of perimenopausal dysfunctional uterine bleeding with low-dose mifepristone is a safe and effective method.
[Key words] Mifepristone;Perimenopause dysfunctional uterine bleeding
功能失调性子宫出血(功血)指非器质性病因引起的异常子宫出血。其病理基础是中枢-下丘脑-垂体-卵巢轴神经内分泌调控失常,也可以是卵巢或子宫局部调控异常所致。常见于青春期及围绝经期妇女,以无排卵性功血多见。围绝经期功血是由于卵巢功能开始衰退,生殖内分泌所引起的子宫出血,根据临床统计,有70%围绝经期妇女发生月经紊乱。米非司酮作为孕激素受体拮抗剂,具有明显的抗孕激素作用,临床上常用于终止妊娠和引产,由于其对子宫内膜增生具有特有的抗雌激素作用,临床上将其用于功血的治疗。本院采用小剂量米非司酮治疗围绝经期功血24例,取得良好效果,现报道如下:
1 资料与方法
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