血管紧张素转换酶基因多态性与小儿过敏性紫癜及紫癜性肾炎的关联性(1)
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[摘要] 目的:探讨血管紧张素转换酶(ACE)基因多态性与小儿过敏性紫癜(HSP)及紫癜性肾炎(HSPN)的相关性。方法:选择106例HSP患儿,其中HSPN患儿32例,在HSPN中单纯性血尿13例,蛋白尿19例,肾功能不全12例,肾脏活检依据ISKDC病理分级,其中Ⅰ～Ⅱ级11例,Ⅲ～Ⅵ 级17例。正常对照儿童100例。通过聚合酶链反应(PCR)检测ACE基因多态性并鉴定其基因型。结果:①HSP患儿与正常对照组间ACE基因型分布差异无统计学意义(P>0.05),但在HSPN组中,DD基因型及D等位基因频率则明显高于正常对照组(P<0.016 7);②在HSPN中,DD基因型在表现有大量蛋白尿(尿蛋白>50 mg/24 h)、明显血尿(镜检RBC>3+/HP)及非轻度肾脏病理损害(Ⅲ～Ⅵ级)组中的频率明显高于对照组(P<0.05),但在肾功能正常组(尿肌酐<1.5 mg/dl)和肾功能不全组(尿肌酐>1.5 mg/dl)中,ACE基因型分布则差异无统计学意义(P>0.05)。结论:ACE基因多态性可能与HSP的发病及其HSPN肾功能的改变无关,但可能与HSPN的发病、血尿、蛋白尿及肾脏病理损害的严重程度有关。
[关键词] 过敏性紫癜;过敏性紫癜性肾炎;血管紧张素转换酶;基因多态性
[中图分类号] R554+.6 [文献标识码]A [文章编号]1674-4721(2010)05(a)-005-4
Association between angiotensin-converting enzyme gene polymorphism and children with Henoch-Schonlein purpura and Henoch-Schonlein purpura nephritis
CUI Zhangli, SHI Yan*, YIN Huaiqing, FAN Shulan, LI Hong, YUAN Pingfei
(Department of Pediatric, the First Hospital of Shanxi Medical University, Shanxi Provicne, Taiyuan030001, China)
[Abstract] Objective: To explore the relationship between ACE gene polymorphism and the children with Henoch-Schonlein purpura (HSP) and Henoch-Schonlein purpura nephritis (HSPN). Methods: Choosing 106 cases with HSP, of which 32 cases of children were HSPN. In HSPN group, of which 13 cases were hematuria, 19 cases were proteinuria and 12 cases were renal insufficiency. Renal biopsy was based on ISKDC, of which 11 cases of gradeⅠ-Ⅱ, 17 cases of grade Ⅲ-Ⅵ. Normal control children were 100 cases. Polymerase chain reaction (PCR) was used to detect ACE gene polymorphism and identify their genotype. Results: The frequency of ACE genotypes had no significant difference between children with HSP and normal control group (P>0.05), but the frequency of DD genotype and D allele was significantly higher in children with HSPN than that of normal control group (P<0.016 7); In the HSPN group, the frequency of DD genotype in the performance of massive proteinuria(urine protein>50 mg/24 h), grossive hematuria (microscopic RBC>3+/HP) and non-mild glomerular lesion (grade Ⅲ-Ⅵ) groups were significantly higher than that of control group (P<0 ......
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