盐酸戊乙奎醚治疗急性有机磷农药中毒的临床研究(1)
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2010年11月15日
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[摘要] 目的：观察盐酸戊乙奎醚(长托宁)在抢救急性有机磷农药中毒患者中的临床疗效。方法：将本院进行抢救的47例急性有机磷农药中毒患者作为观察组，给予盐酸戊乙奎醚联合氯解磷定治疗；既往本科应用传统的阿托品加氯解磷定进行抢救的47例急性有机磷中毒患者作为对照组，比较两组患者的临床疗效。结果：观察组的临床疗效、平均住院时间、CHE恢复时间、中毒症状消失时间及意识清醒时间与对照组比较，差异均有统计学意义(P<0.05)；并且不良反应的发生率仅为10.6%，明显比对照组少(P<0.05)。结论：盐酸戊乙奎醚(长托宁)治疗急性有机磷农药中毒患者疗效确切，不良反应少，值得广泛应用。
[关键词] 急性有机磷农药中毒；盐酸戊乙奎醚；氯解磷定
[中图分类号] R781.6+6 [文献标识码]A[文章编号]1674-4721(2010)11(b)-042-02
The clinical study of penehyclidine hydrochloride combined with pralidoxime chloride in treatment of acute organophosphate insecticides toxicosis
ZHANG Jianxin
(Department of Emergency, the First Affiliated Hospital of Xinxiang Medical College, He'nan Province, Weihui 453100, China)
[Abstract] Objective: To observe the penehyclidine hydrochloride(PHC) in treatment of patients with acute organophosphorus pesticide poisoning in the clinical efficacy. Methods: The hospital for emergency treatment of 47 cases of patients with acute organophosphorus pesticide poisoning as the observation group, given the joint penehyclidine hydrochloride pralidoxime chloride treatment; previous traditional undergraduate application of atropine to rescue the chlorination of 47 pralidoxime cases of acute organophosphate poisoning as a control group of patients, the clinical efficacy of two groups were compared. Results: The clinical observation group, the average length of stay, CHE recovery time, poisoning symptoms time and conscious of time and the control group, the difference was statistically significant(P<0.05); and the incidence rate of adverse reactions was 10.6%, significantly less than the control group(P<0.05). Conclusion: Penehyclidine hydrochloride(PHC) in the treatment of patients with acute organophosphorus pesticide poisoning is effective and less adverse reaction, it is widely used.
[Key words] Acute organophosphorus pesticide poisoning; Penehyclidine hydrochloride; Pralidoxime chloride
有机磷农药在我国应用广泛，由其所导致的急性有机磷农药中毒(AOPP)在我国有很高的发生率，该病因其毒性大，预后很差。以往临床上多用阿托品联合氯解磷定进行抢救，但是往往由于阿托品的用法和用量不正确，导致患者死亡率极高，据报道可达67.8%[1]。近年来新一代抗胆碱药物盐酸戊乙奎醚(长托宁)开始应用于临床抢救AOPP患者，本科应用盐酸戊乙奎醚对AOPP患者进行了抢救，发现与传统的阿托品抢救急性有机磷农药中毒相比 ......
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