前列地尔治疗早期糖尿病视网膜病变的临床观察(1)
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[摘要] 目的：观察前列地尔注射液(脂微球载体制剂)对早期糖尿病视网膜病变的治疗效果。方法：收集2008年7月～2010年4月Ⅰ～Ⅲ期糖尿病视网膜病变患者109例(210眼)，将其随机分为治疗组和对照组，其中对照组57例(108眼)，治疗组52例(102眼)。对照组给予维生素B1、维生素C、甲钴胺、丹参等治疗，治疗组在上述治疗的基础上加用前列地尔10 μg静注QD，所有患者连续用药2周。观察治疗前后患者视力、视野及眼底血管造影的变化情况。结果：治疗组用药2周后与治疗前相比视力明显提高(P<0.01)，视野灰度值(MD)降低(P<0.01)，眼底微动脉瘤及出血斑数量减少(P<0.01)；对照组治疗后与治疗前相比视力轻度提高(P<0.05)，而MD、眼底微动脉瘤及出血斑数无明显改变(P>0.05)；两组间治疗后结果比较，差异有统计学意义(P<0.05，P<0.01)。结论：前列地尔注射液对早期糖尿病性视网膜病变有明显的治疗作用。
[关键词] 前列地尔；糖尿病视网膜病变；疗效；临床观察
[中图分类号] R587.2 [文献标识码] B [文章编号] 1674-4721(2011)11(c)-070-02
Clinical observation of prostaglandin E1 in treating the early diabetic retinopathy
WU Fanglai, WANG Sihu, HUANG Daxiang, BO Wei
Department of Endocrinology, Anqing Municipal Hospital, Anhui Province, Anqing 246300, China
[Abstract] Objective: To study the clinical effects of prostaglandin E1(PGE1) in treating the early diabetic retinopathy (DR). Methods: 109 cases (210 eyes) withⅠ-Ⅲ DR degree were colleted. There were 57 cases (108 eyes) in the contrast group and 52 cases (102 eyes) in the treatment group. The cases in contrast group were treated with vitamin B1, vitamin C, mecobalamine, miltiorrhizae and so on. The cases in treatment group were treated with PGE1 10 μg i.v qd besides above-mentioned treatment. All patients were treated continuously for 2 weeks. The changes in vision, visual fields and angiography fluorescence fundus were observed before and after treatment. Results: Compared with the results before treatment, the treatment group vision was improved obviously (P<0.01), visual fields (MD) decreased (P<0.01), and the quantity of retinal mieroanearysm and blood-blotch decreased (P<0.01); In the contrast group, vision was improved only (P<0.05); The results for treatment group were obviously different from that of contrast group (P<0.05, P<0.01). Conclusion: PGE1 has obvious treatment effects on the early DR.
[Key words] Prostaglandin E1; Diabetic retinopathy; Effect; Clinical observation
糖尿病视网膜病变(diabetic retinopathy，DR)是糖尿病最常见和严重的微血管并发症之一，致盲率很高[1]。近年来大量研究报道显示DR的发生和发展除与糖尿病病程及血糖控制情况密切相关外，高血压、高血脂、高血液黏滞状态等也是其发生发展的相关因素[2-3] ......
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