脑出血微创置管吸引术对老年脑出血患者血清IL—6、TNF—α和hs—CRP的影响分析(1)
[摘要] 目的 探讨脑出血微创置管吸引术对老年脑出血患者血清IL-6、TNF-α和hs-CRP的影响。 方法 选取本院2011年5月～2013年5月收治的64例老年脑出血患者作为研究对象，随机分为对照组和观察组，各32例。对照组给予常规药物保守治疗，观察组在对照组的基础上行钻孔置管血肿抽吸液化引流术，比较两组术后2、7、15和30 d的IL-6、TNF-α和hs-CRP水平。 结果 观察组术后7、15 d的血清IL-6、TNF-α和hs-CRP水平显著低于对照组，差异有统计学意义(P<0.05)。两组术后2、30 d的血清IL-6、TNF-α和hs-CRP水平比较，差异无统计学意义(P>0.05)。 结论 脑出血微创置管吸引术治疗老年脑出血效果显著，能降低血清炎性因子水平，防止炎性介质损伤脑组织，值得临床推广应用。
[关键词] 脑出血微创置管吸引术；老年；脑出血；血清炎性因子
[中图分类号] R743.34 [文献标识码] A [文章编号] 1674-4721(2015)06(a)-0061-03
Influence analysis of cerebral hemorrhage minimally invasive catheter aspiration for serum IL-6，TNF-α and hs-CRP in elderly patients with cerebral hemorrhage
XIAO Wei-li YUAN Shao-peng HU Jian-jun
Department of Neurosurgery，People′s Hospital of Sanshui District of Foshan City in Guangdong Province，Foshan 528100，China
[Abstract] Objective To explore the influence of cerebral hemorrhage minimally invasive catheter aspiration for serum IL-6，TNF-α and hs-CRP in elderly patients with cerebral hemorrhage. Methods 64 cases with cerebral hemorrhage in our hospital from May 2011 to May 2013 were selected and randomly divided into the control group and the observation group，32 cases in each group.The control group was treated with conventional conservative treatment，the observation group was treated with hematoma aspiration and liquefaction for drilling catheter on the basis of the control group.The level of IL-6，TNF-α and hs-CRP in postoperative 2，7，15，30 d in two groups was compared. Results The level of serum IL-6，TNF-α and hs-CRP in postoperative 7，15 d of observation group was lower than that of the control group，with significant difference (P<0.05).The level of serum IL-6，TNF-α and hs-CRP in postoperative 2，30 d between two groups was no significant difference(P>0.05). Conclusion The application effect of cerebral hemorrhage minimally invasive catheter aspiration in the treatment of elderly patients with cerebral hemorrhage is significant，which can reduce serum levels of inflammatory cytokines，prevent damage to brain tissue，it is worthy of clinical promotion and application.
[Key words] Cerebral hemorrhage minimally invasive catheter aspiration；The elderly；Cerebral hemorrhage；Serum inflammatory factor
老年脑出血是严重危害人类健康的脑血管疾病，具有高发病率、高致残率和高致死率等特点[1]。临床治疗老年脑出血的难度较大，单纯内科保守治疗周期长，疗效不尽满意，患者死亡率高[2]。高血压性脑出血是临床神经外科的常见病、多发病，其中基底节出血最常见，约占60%，大多是由于各种因素引起血压骤升，导致颅内动脉破裂形成血肿，产生占位效应，并且随着时间的推进，脑组织水肿将进一步加重，脑功能发生不可逆性损害，因此在脑出血发生后早期采取有效措施清除颅内血肿、恢复受损神经功能是此类患者临床治疗的关键。研究结果显示，有效清除颅内血肿和组织内炎性因子，对于老年脑出血患者的疗效和预后至关重要[3]。本研究选取本院的老年脑出血患者作为研究对象，旨在探讨脑出血微创置管吸引术对其血清IL-6、TNF-α和hs-CRP的影响。 (肖伟利 元少鹏 胡建军)
[关键词] 脑出血微创置管吸引术；老年；脑出血；血清炎性因子
[中图分类号] R743.34 [文献标识码] A [文章编号] 1674-4721(2015)06(a)-0061-03
Influence analysis of cerebral hemorrhage minimally invasive catheter aspiration for serum IL-6，TNF-α and hs-CRP in elderly patients with cerebral hemorrhage
XIAO Wei-li YUAN Shao-peng HU Jian-jun
Department of Neurosurgery，People′s Hospital of Sanshui District of Foshan City in Guangdong Province，Foshan 528100，China
[Abstract] Objective To explore the influence of cerebral hemorrhage minimally invasive catheter aspiration for serum IL-6，TNF-α and hs-CRP in elderly patients with cerebral hemorrhage. Methods 64 cases with cerebral hemorrhage in our hospital from May 2011 to May 2013 were selected and randomly divided into the control group and the observation group，32 cases in each group.The control group was treated with conventional conservative treatment，the observation group was treated with hematoma aspiration and liquefaction for drilling catheter on the basis of the control group.The level of IL-6，TNF-α and hs-CRP in postoperative 2，7，15，30 d in two groups was compared. Results The level of serum IL-6，TNF-α and hs-CRP in postoperative 7，15 d of observation group was lower than that of the control group，with significant difference (P<0.05).The level of serum IL-6，TNF-α and hs-CRP in postoperative 2，30 d between two groups was no significant difference(P>0.05). Conclusion The application effect of cerebral hemorrhage minimally invasive catheter aspiration in the treatment of elderly patients with cerebral hemorrhage is significant，which can reduce serum levels of inflammatory cytokines，prevent damage to brain tissue，it is worthy of clinical promotion and application.
[Key words] Cerebral hemorrhage minimally invasive catheter aspiration；The elderly；Cerebral hemorrhage；Serum inflammatory factor
老年脑出血是严重危害人类健康的脑血管疾病，具有高发病率、高致残率和高致死率等特点[1]。临床治疗老年脑出血的难度较大，单纯内科保守治疗周期长，疗效不尽满意，患者死亡率高[2]。高血压性脑出血是临床神经外科的常见病、多发病，其中基底节出血最常见，约占60%，大多是由于各种因素引起血压骤升，导致颅内动脉破裂形成血肿，产生占位效应，并且随着时间的推进，脑组织水肿将进一步加重，脑功能发生不可逆性损害，因此在脑出血发生后早期采取有效措施清除颅内血肿、恢复受损神经功能是此类患者临床治疗的关键。研究结果显示，有效清除颅内血肿和组织内炎性因子，对于老年脑出血患者的疗效和预后至关重要[3]。本研究选取本院的老年脑出血患者作为研究对象，旨在探讨脑出血微创置管吸引术对其血清IL-6、TNF-α和hs-CRP的影响。 (肖伟利 元少鹏 胡建军)