双联抗血小板聚集疗法用于糖尿病合并脑梗死的临床治疗作用(1)
[摘要]目的 探讨糖尿病合并脑梗死应用双联抗血小板聚集疗法的临床意义。方法 选取2015年5月～2017年2月我院收治的72例糖尿病合并脑梗死患者作为研究对象，按照随机数字表法分为对照组和观察组，各36例。对照组采取氯吡格雷单独治疗，观察组予以双联抗血小板聚集疗法，在对照组基础上联合阿司匹林。观察两组治疗前后的神经功能缺损、日常生活能力以及不良事件发生情况。结果 两组治疗后的Barthel评分高于治疗前，NIHSS评分低于治疗前，差异有统计学意义(P<0.05)。观察组治疗后的Barthel评分高于对照组，NIHSS评分低于对照组，差异有统计学意义(P<0.05)。两组的不良事件发生率比较，差异无统计学意义(P>0.05)。结论 糖尿病合并脑梗死采用双联抗血小板聚集疗法的临床价值较高，可有效改善神经功能、生活能力，且安全性高。
[关键词]脑梗死；糖尿病；双联抗血小板聚集疗法
[中图分类号] R587.1 [文献标识码] A [文章编号] 1674-4721(2017)08(b)-0034-03
Clinical therapy effect of double antiplatelet aggregation therapy in the treatment of diabetes mellitus complicated with cerebral infarction
ZHAO Yu-xia LIU Qiao-qiao
Department of Pharmacy，Central Hospital of Zibo City in Shandong Province，Zibo 255031，China
[Abstract]Objective To investigate the clinical significance of double antiplatelet aggregation therapy in diabetic mellitus patients with cerebral infarction.Methods From May 2015 to February 2017，72 patients with diabetes mellitus complicated with cerebral infarction in our hospital were selected and divided into the control group and the observation group according to the random number method，36 cases in each group.The control group was treated with Clopidogrel alone，and the observation group was treated with double antiplatelet aggregation therapy，on the basis of the control group，Aspirin was added.The neurological deficits，daily living ability and adverse events were observed before and after treatment in the two groups.Results The Barthel score in the two groups after treatment was higher than that before treatment，and the NIHSS score in the two groups after treatment was lower than that before treatment，with significant difference (P<0.05).The Barthel score in the observation group after treatment was higher than that in the control group，and the NIHSS score in the observation group after treatment was lower than that in the control group，with significant difference (P<0.05).There was no significant difference in the incidence rate of adverse events between the two groups (P>0.05).Conclusion Double antiplatelet aggregation therapy in the treatment of diabetes mellitus complicated with cerebral infarction has high clinical value，which can effectively improve neurological function and living ability and high safety.
[Key words]Cerebral infarction；Diabetes mellitus；Double antiplatelet aggregation therapy
糖尿病以慢性高血糖為特征，患者通常会出现多脏器功能减退、长期损伤等现象，其中心脑血管并发症是糖尿病患者最为主要的致死因素[1-2]。作为常见合并症，糖尿病合并脑梗死发病机制复杂，系因多种因素共同作用所致，极易导致患者死亡、残疾，临床治疗以控制血糖，及时予以抗血小板聚集、抗凝等措施为主。常规治疗虽可获得一定效果，但并不理想，双联抗血小板聚集疗法则能够通过协同作用更好地改善血小板聚集状况。本研究旨在探讨糖尿病合并脑梗死予以双联抗血小板聚集疗法的应用意义。, 百拇医药(赵玉霞 刘巧巧)
[关键词]脑梗死；糖尿病；双联抗血小板聚集疗法
[中图分类号] R587.1 [文献标识码] A [文章编号] 1674-4721(2017)08(b)-0034-03
Clinical therapy effect of double antiplatelet aggregation therapy in the treatment of diabetes mellitus complicated with cerebral infarction
ZHAO Yu-xia LIU Qiao-qiao
Department of Pharmacy，Central Hospital of Zibo City in Shandong Province，Zibo 255031，China
[Abstract]Objective To investigate the clinical significance of double antiplatelet aggregation therapy in diabetic mellitus patients with cerebral infarction.Methods From May 2015 to February 2017，72 patients with diabetes mellitus complicated with cerebral infarction in our hospital were selected and divided into the control group and the observation group according to the random number method，36 cases in each group.The control group was treated with Clopidogrel alone，and the observation group was treated with double antiplatelet aggregation therapy，on the basis of the control group，Aspirin was added.The neurological deficits，daily living ability and adverse events were observed before and after treatment in the two groups.Results The Barthel score in the two groups after treatment was higher than that before treatment，and the NIHSS score in the two groups after treatment was lower than that before treatment，with significant difference (P<0.05).The Barthel score in the observation group after treatment was higher than that in the control group，and the NIHSS score in the observation group after treatment was lower than that in the control group，with significant difference (P<0.05).There was no significant difference in the incidence rate of adverse events between the two groups (P>0.05).Conclusion Double antiplatelet aggregation therapy in the treatment of diabetes mellitus complicated with cerebral infarction has high clinical value，which can effectively improve neurological function and living ability and high safety.
[Key words]Cerebral infarction；Diabetes mellitus；Double antiplatelet aggregation therapy
糖尿病以慢性高血糖為特征，患者通常会出现多脏器功能减退、长期损伤等现象，其中心脑血管并发症是糖尿病患者最为主要的致死因素[1-2]。作为常见合并症，糖尿病合并脑梗死发病机制复杂，系因多种因素共同作用所致，极易导致患者死亡、残疾，临床治疗以控制血糖，及时予以抗血小板聚集、抗凝等措施为主。常规治疗虽可获得一定效果，但并不理想，双联抗血小板聚集疗法则能够通过协同作用更好地改善血小板聚集状况。本研究旨在探讨糖尿病合并脑梗死予以双联抗血小板聚集疗法的应用意义。, 百拇医药(赵玉霞 刘巧巧)