自身免疫性甲状腺功能紊乱孕妇血清甲状腺过氧化酶抗体的变化及其临床意义(1)
[摘要]目的 研究自身免疫性甲狀腺功能紊乱孕妇血清甲状腺过氧化酶抗体的变化及其临床意义。方法 选取2016年12月～2018年12月我院收治的210例孕妇为研究对象，通过筛查得到自身免疫性甲状腺功能紊乱孕妇52例作为观察组，其余非甲状腺功能紊乱孕妇158例作为对照组。按照促甲状腺激素(TSH)水平正常(正常范围0.35～5.50 μU/ml)与否将观察组分为TSH正常组(n=8)和TSH异常组(n=44)。检测和比较两组的TSH、甲状腺过氧化物酶抗体(TPOAb)指标、TPOAb阳性率及TSH正常组和异常组的TPOAb阳性率。结果 观察组TSH为(8.37±3.90)μU/ml、TPOAb为(173.30±48.32)U/ml，均高于对照组的(1.27±0.58)μU/ml、(30.55±3.22)U/ml(P<0.05)。观察组TPOAb阳性率为80.77%，高于对照组的11.39%(P<0.05)。TSH异常组的TPOAb阳性率为47.73%，高于TSH正常组的12.50%(P<0.05)。结论 自身免疫性甲状腺功能紊乱孕妇，其TSH、TPOAb等相关指标与正常孕妇相比差异明显，THS指标正常和异常的孕妇之间，TPOAb水平也有显著差异。因此对于自身免疫性甲状腺功能紊乱孕妇，TPOAb具有较高的临床诊断价值。
[关键词]血清甲状腺过氧化物酶抗体;自身免疫性甲状腺功能紊乱;临床诊断价值
[中图分类号] R581.4 [文献标识码] A [文章编号] 1674-4721(2019)12(c)-0182-03
Changes and clinical significance of serum thyroid peroxide antibody in pregnant women with autoimmune thyroid dysfunction
LI Wen-zhong LI Li-li LAI Guan-zhen PENG Fo-chen FENG Xu-fen
Department of Clinical Laboratory， Ganzhou Maternal and Child Health Hospital， Jiangxi Province， Ganzhou 341000， China
[Abstract] Objective To study the changes and clinical significance of serum thyroid peroxide antibody in pregnant women with autoimmune thyroid dysfunction. Methods From December 2016 to December 2018， 210 pregnant women with autoimmune thyroid dysfunction admitted to our hospital were selected as the study subjects. Through screening， 52 pregnant women with autoimmune thyroid dysfunction were selected as observation group and 158 pregnant women without thyroid dysfunction were selected as control group. The observation group was divided into normal TSH group (n=8) and abnormal TSH group (n=44) according to whether the TSH level was normal (normal range 0.35-5.50 μU/ml). The indexes of TSH， thyroid peroxidase antibody (TPOAb)， the positive rate of TPOAb in the two groups， and the positive rate of TPOAb in normal TSH group and abnormal TSH group were detected and compared. Results TSH and TPOAb in the observation group were (8.37±3.90) μU/ml and (173.30±48.32) U/ml respectively， which were higher than those in the control group for (1.27±0.58) μU/ml and (30.55±3.22) U/ml (P<0.05). The positive rate of TPOAb in the observation group was 80.77%， higher than 11.39% in the control group (P<0.05). The positive rate of TPOAb in abnormal TSH group was 47.73%， which was higher than 12.50% in normal TSH group (P<0.05). Conclusion The TSH， TPOAb and other related indexes of pregnant women with autoimmune thyroid dysfunction are significantly different from those of normal pregnant women. The level of TPOAb is also significantly different between pregnant women with normal and abnormal THS indexes. Therefore， TPOAb has high clinical diagnostic value for pregnant women with autoimmune thyroid dysfunction., 百拇医药(李文忠 李丽丽 赖观珍)
[关键词]血清甲状腺过氧化物酶抗体;自身免疫性甲状腺功能紊乱;临床诊断价值
[中图分类号] R581.4 [文献标识码] A [文章编号] 1674-4721(2019)12(c)-0182-03
Changes and clinical significance of serum thyroid peroxide antibody in pregnant women with autoimmune thyroid dysfunction
LI Wen-zhong LI Li-li LAI Guan-zhen PENG Fo-chen FENG Xu-fen
Department of Clinical Laboratory， Ganzhou Maternal and Child Health Hospital， Jiangxi Province， Ganzhou 341000， China
[Abstract] Objective To study the changes and clinical significance of serum thyroid peroxide antibody in pregnant women with autoimmune thyroid dysfunction. Methods From December 2016 to December 2018， 210 pregnant women with autoimmune thyroid dysfunction admitted to our hospital were selected as the study subjects. Through screening， 52 pregnant women with autoimmune thyroid dysfunction were selected as observation group and 158 pregnant women without thyroid dysfunction were selected as control group. The observation group was divided into normal TSH group (n=8) and abnormal TSH group (n=44) according to whether the TSH level was normal (normal range 0.35-5.50 μU/ml). The indexes of TSH， thyroid peroxidase antibody (TPOAb)， the positive rate of TPOAb in the two groups， and the positive rate of TPOAb in normal TSH group and abnormal TSH group were detected and compared. Results TSH and TPOAb in the observation group were (8.37±3.90) μU/ml and (173.30±48.32) U/ml respectively， which were higher than those in the control group for (1.27±0.58) μU/ml and (30.55±3.22) U/ml (P<0.05). The positive rate of TPOAb in the observation group was 80.77%， higher than 11.39% in the control group (P<0.05). The positive rate of TPOAb in abnormal TSH group was 47.73%， which was higher than 12.50% in normal TSH group (P<0.05). Conclusion The TSH， TPOAb and other related indexes of pregnant women with autoimmune thyroid dysfunction are significantly different from those of normal pregnant women. The level of TPOAb is also significantly different between pregnant women with normal and abnormal THS indexes. Therefore， TPOAb has high clinical diagnostic value for pregnant women with autoimmune thyroid dysfunction., 百拇医药(李文忠 李丽丽 赖观珍)