双相情感障碍丙戊酸钠治疗过程中POLG基因突变1例分析(4)
[20]Sitarz KS，Elliott HR，Karaman，Betül S，et al.Valproic acid triggers increased mitochondrial biogenesis in POLG-deficient fibroblasts[J].Mol Genet Metab，2014，112(1)：57-63.
[21]Rajakulendran S，Pitceathly RDS，Taanman JW，et al.A Clinical，Neuropathological andGenetic Study of Homozygous A467T POLG-Related Mitochondrial Disease[J].PLoS One，2016，11(1)：e0145500.
[22]Hynynen J，Komulainen T，Tukiainen E，et al.Acute liver failure in patients withPOLG1 mutations after valproate exposure and their prognosis after liver transplantation[J].Liver Transpl，2014，20(11)：1402-1412.
[23]London F，Hadhoum N，Outteryck O，et al.Late-onset of Alpers-Huttenlocher syndrome：an unusual cause of refractory epilepsy and liver failure[J].Acta Neurol Belg，2017，117(1)：399-401.
[24]Saneto RP，Lee IC，Koenig MK，et al.POLG DNA testing as an emerging standard of care before instituting valproic acid therapy for pediatric seizure disorders[J].Seizure，2010， 19(3)：140-146.
[25]丙戊酸鈉缓释片说明书[EB/OL].https：//baike.baidu.com/item/丙戊酸钠缓释片/865696？fr=aladdin.
(收稿日期：2019-12-02), http://www.100md.com(刘超 易正辉 吕钦谕 王培涓)
[21]Rajakulendran S，Pitceathly RDS，Taanman JW，et al.A Clinical，Neuropathological andGenetic Study of Homozygous A467T POLG-Related Mitochondrial Disease[J].PLoS One，2016，11(1)：e0145500.
[22]Hynynen J，Komulainen T，Tukiainen E，et al.Acute liver failure in patients withPOLG1 mutations after valproate exposure and their prognosis after liver transplantation[J].Liver Transpl，2014，20(11)：1402-1412.
[23]London F，Hadhoum N，Outteryck O，et al.Late-onset of Alpers-Huttenlocher syndrome：an unusual cause of refractory epilepsy and liver failure[J].Acta Neurol Belg，2017，117(1)：399-401.
[24]Saneto RP，Lee IC，Koenig MK，et al.POLG DNA testing as an emerging standard of care before instituting valproic acid therapy for pediatric seizure disorders[J].Seizure，2010， 19(3)：140-146.
[25]丙戊酸鈉缓释片说明书[EB/OL].https：//baike.baidu.com/item/丙戊酸钠缓释片/865696？fr=aladdin.
(收稿日期：2019-12-02), http://www.100md.com(刘超 易正辉 吕钦谕 王培涓)