西酞普兰与氟西汀治疗抑郁症的对照研究
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【摘要】目的对比西酞普兰与氟西汀治疗抑郁症的疗效和安全性。 方法60例抑郁症患者随机分为西酞普兰组和氟西汀组，每组30例，分别给予西酞普兰和氟西汀治疗，疗程6周。以汉密尔顿抑郁量表(HAMD)和汉密尔顿焦虑量表(HAMA)评定疗效，以治疗中出现的症状量表(TESS)评定不良反应。 结果治疗2、4、6周，西酞普兰组与氟西汀组HAMD、HAMA评分均显著下降(P均<0.05)，两组疗效无显著性差异(P>0.05)。西酞普兰组TESS评分比氟西汀组低，两组有显著差异(P<0.05)。 结论西酞普兰与氟西汀治疗抑郁症的疗效相当，但西酞普兰不良反应较氟西汀轻，更安全。
【关键词】抑郁症；西酞普兰；氟西汀
A controlled study in the treatment of depression with escitalopram and fluoxetine LI Shu-yun,WU Hong-jun,ZHOU Gui-lan.The Fifth Peoples Hospital of Jiujiang,Jiujiang 332000,China
【Abstract】ObjectiveTo compare the efficacy and safety of escitalopram and fluoxetine in the treatment of major depression.Methods60 patients diagnosed as depression were randomly assigned into escitaloptam group (n=29)which received escitaloptam treatment and fluoxetine group (n=27)which received fluoxetine treatment for 6 weeks .Clinical efficacy was evaluated with Hamilton depression scale(HAMD)and Hamilton anxiety scale(HAMA),and adverse reactions and safety were assessed with treatment symptom scale(TESS) ......
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