加巴喷丁联合氟芬那酸丁酯软膏治疗带状疱疹后遗神经痛48例临床观察(1)
【摘要】 目的：評价加巴喷丁联合氟芬那酸丁酯软膏治疗带状疱疹后遗神经痛的临床效果。方法：将入选的94例患者随机分为两组，治疗组
(48例)每日分3次口服加巴喷丁300～900 mg，最大1200 mg，同时予氟芬那酸丁酯软膏均匀外搽皮损，3次/d。对照组(46例)口服卡马西平0.1 g，消炎痛25 mg，均3次/d。两组疗程均为4周。结果：治疗4周后，治疗组总有效率为87.50%，对照组为69.57%，差异有统计学意义(字2=4.51，P<0.05)。两组治疗前VAS评分比较差异无统计学意义(t=0.578，P>0.05)，治疗4周后，治疗组低于对照组，疼痛缓解程度较大，差异有统计学意义(t=11.190，P<0.05)。两组患者治疗过程和随访期间，无不良反应发生。结论：带状疱疹后遗神经痛患者，加巴喷丁联合氟芬那酸丁酯软膏应用，能迅速缓解疼痛症状，显著提升患者生活质量，不良反应较少，临床值得运用。
【关键词】 带状疱疹后遗神经痛； 加巴喷丁； 氟芬那酸丁酯
doi：10.14033/j.cnki.cfmr.2017.6.005 文献标识码 B 文章编号 1674-6805(2017)06-0009-02
Therapeutic Effect Observation of Butyl Flufenamate Ointment Combined with Gabapentin in the Treatment of 48 Cases of Post-herpetic Neuralgia/LIU Bin，ZHU Li.//Chinese and Foreign Medical Research，2017，15(6)：9-10
【Abstract】 Objective：To investigate the clinical effects of Butyl Flufenamate Ointment combined with Gabapentin in patients with post-herpetic neuralgia(PHN).Method：94 patients with PHN were randomized divided into treatment group(n=48) and control group(n=46).The treatment group received oral Gabapentin (300-900 mg) with a maximum dose of 1200 mg，3 times a day，besides Butyl Flufenamate Ointment was applied to the skin lesionevenly，3 times a day.The control group received oral Carbamazepine(100 mg) and Indomethacin(25 mg)，3 times a day.Both groups were treated for 4 weeks.Result：After 4 weeks of treatment，the total effective rate of the treatment group was 87.50%，while the control group was 69.57%，the difference was statistically significant(字2=4.51，P<0.05).Before the treatment，the difference in VAS in both groups showed no statistical significance(t=0.578， P>0.05).After 4 weeks of treatment，the VAS of the treatment group was lower than that of the control group，and the difference was statistically significant(t=11.190，P<0.05).There was no adverse reaction between the two groups during the course of treatment and follow-up.Conclusion：Butyl Flufenamate Ointment combined with Gabapentin can relieve the symptoms of pain in patients with post-herpetic neuralgia and improve the quality of life with less adverse effects， and it is worth using clinically.
【Key words】 Post-herpetic neuralgia； Gabapentin； Butyl Flufenamate
First-author’s address：Wuhan No.9 Hospital，Wuhan 430081，China
带状疱疹后遗神经痛(postherpetic neuralgia，PHN)患者常常因为异常性疼痛和烧灼样疼痛，生活质量显著下降，加巴喷丁作为抗癫痫药物之一，同时也具有显著缓解疼痛的作用，常被推荐为治疗PHN的首选药物[1]。本研究旨在分析探讨笔者所在医院2009年7月-2012年5月对于48例带状疱疹后遗神经痛患者，采用加巴喷丁联合氟芬那酸丁酯软膏治疗效果，现总结如下。
1 资料与方法
1.1 一般资料, http://www.100md.com(刘斌 朱里)
(48例)每日分3次口服加巴喷丁300～900 mg，最大1200 mg，同时予氟芬那酸丁酯软膏均匀外搽皮损，3次/d。对照组(46例)口服卡马西平0.1 g，消炎痛25 mg，均3次/d。两组疗程均为4周。结果：治疗4周后，治疗组总有效率为87.50%，对照组为69.57%，差异有统计学意义(字2=4.51，P<0.05)。两组治疗前VAS评分比较差异无统计学意义(t=0.578，P>0.05)，治疗4周后，治疗组低于对照组，疼痛缓解程度较大，差异有统计学意义(t=11.190，P<0.05)。两组患者治疗过程和随访期间，无不良反应发生。结论：带状疱疹后遗神经痛患者，加巴喷丁联合氟芬那酸丁酯软膏应用，能迅速缓解疼痛症状，显著提升患者生活质量，不良反应较少，临床值得运用。
【关键词】 带状疱疹后遗神经痛； 加巴喷丁； 氟芬那酸丁酯
doi：10.14033/j.cnki.cfmr.2017.6.005 文献标识码 B 文章编号 1674-6805(2017)06-0009-02
Therapeutic Effect Observation of Butyl Flufenamate Ointment Combined with Gabapentin in the Treatment of 48 Cases of Post-herpetic Neuralgia/LIU Bin，ZHU Li.//Chinese and Foreign Medical Research，2017，15(6)：9-10
【Abstract】 Objective：To investigate the clinical effects of Butyl Flufenamate Ointment combined with Gabapentin in patients with post-herpetic neuralgia(PHN).Method：94 patients with PHN were randomized divided into treatment group(n=48) and control group(n=46).The treatment group received oral Gabapentin (300-900 mg) with a maximum dose of 1200 mg，3 times a day，besides Butyl Flufenamate Ointment was applied to the skin lesionevenly，3 times a day.The control group received oral Carbamazepine(100 mg) and Indomethacin(25 mg)，3 times a day.Both groups were treated for 4 weeks.Result：After 4 weeks of treatment，the total effective rate of the treatment group was 87.50%，while the control group was 69.57%，the difference was statistically significant(字2=4.51，P<0.05).Before the treatment，the difference in VAS in both groups showed no statistical significance(t=0.578， P>0.05).After 4 weeks of treatment，the VAS of the treatment group was lower than that of the control group，and the difference was statistically significant(t=11.190，P<0.05).There was no adverse reaction between the two groups during the course of treatment and follow-up.Conclusion：Butyl Flufenamate Ointment combined with Gabapentin can relieve the symptoms of pain in patients with post-herpetic neuralgia and improve the quality of life with less adverse effects， and it is worth using clinically.
【Key words】 Post-herpetic neuralgia； Gabapentin； Butyl Flufenamate
First-author’s address：Wuhan No.9 Hospital，Wuhan 430081，China
带状疱疹后遗神经痛(postherpetic neuralgia，PHN)患者常常因为异常性疼痛和烧灼样疼痛，生活质量显著下降，加巴喷丁作为抗癫痫药物之一，同时也具有显著缓解疼痛的作用，常被推荐为治疗PHN的首选药物[1]。本研究旨在分析探讨笔者所在医院2009年7月-2012年5月对于48例带状疱疹后遗神经痛患者，采用加巴喷丁联合氟芬那酸丁酯软膏治疗效果，现总结如下。
1 资料与方法
1.1 一般资料, http://www.100md.com(刘斌 朱里)