甘草泻心汤加减联合穴位贴敷治疗化疗相关性腹泻临床观察(1)
【摘要】 目的：观察甘草泻心汤加减联合穴位贴敷治疗化疗相关性腹泻的临床效果。方法：将所有入选病例随机分为两组，对照组予以奥曲肽+双歧杆菌常规治疗，观察组在对照组常规治疗基础上予以甘草泻心汤加减口服+穴位贴敷治疗，并观察其临床疗效差异。结果：对照组30例患者中显效5例，有效17例，无效8例，总有效率73.34%;观察组30例患者中显效8例，有效20例，无效2例，总有效率为93.34%。差异有统计学意义(P<0.05)。结论：在常规治疗上加用甘草泻心汤加减口服联合穴位贴敷能够改善化疗相关性腹泻，降低腹泻次数，减少全身症状，增强患者对化疗的耐受性。
【关键词】 化疗相关性腹泻 甘草泻心汤 穴位贴敷
[Abstract] Objective： To observe the clinical efficacy of Gancao Xiexin Tang combined with acupoint application for the treatment of chemotherapy induced diarrhea. Method： All the cases to be chosen were randomly divided into two groups. The control group was given routine treatment with Octreotide+Bifidobacterium， while the observation group was given Gancao Xiexin Tang and acupoint application on the basis of the control group， and the difference of treatment effect was observed between the two groups. Result： The thirty patients in the control group， 5 cases were markedly effective， 17 cases were effective， 8 cases were ineffective， and the total effective rate was 73.34%. The thirty patients in the observation group， 8 cases were markedly effective， 20 cases were effective， 2 cases were ineffective， and the total effective rate was 93.34%. The difference was significant (P<0.05). Conclusion： On the basis of conventional treatment， Gancao Xiexin Tang combined with acupoint application can improve the symptoms of chemotherapy induced diarrhea， decrease the number of diarrhea， reduce the general conditions and enhance the survivability on chemotherapy.
[Key words] Chemotherapy induced diarrhea Gancao Xiexin Tang Acupoint application
First-author’s address： Yancheng Dafeng Traditional Chinese Medicine Hospital， Yancheng 224100， China
近些年來由于生存环境的不断恶化及生活方式的急剧转变，恶性肿瘤的发病率不断增加，极大地威胁着人们健康。化疗作为恶性肿瘤治疗的重要手段之一，在控制癌细胞生长或杀死癌细胞活性的同时，对机体正常组织也起到不可避免的毒害作用，化疗相关性腹泻(CID)是其中常见的不良反应之一[1]。若未能妥善处理则可致机体电解质紊乱，肾素、血容量降低，出现休克甚至危及生命。临床上常规应用奥曲肽联合双歧杆菌治疗CID，虽疗效肯定，但仍有部分患者无明显好转，笔者尝试常规治疗上加用甘草泻心汤加减口服联合穴位贴敷治疗化疗相关性腹泻，收到不错的治疗效果，现作如下总结。
1 资料与方法
1.1 一般资料
研究对象为2013年10月-2018年10月笔者所在医院各类恶性肿瘤化疗期间出现腹泻症状的60例患者，肿瘤的分期与类别不限，纳入标准：(1)经细胞学或病理学检查诊断为恶性肿瘤，患者KPS评分>60分。(2)预计生存期大于3个月。(3)拟行化疗方案至少2周期的化疗患者。(4)依从性较好，可随访。排除标准：(1)在化疗前有慢性腹泻病史(大便次数>3次/d)。(2)合并有消化道出血、严重的电解质紊乱、急性或亚急性肠梗阻、酸碱失衡。(3)化疗前3个月使用抗生素或正在接受抗生素治疗>1周。入组病例出现以下情况者考虑剔除：(1)因故未能坚持完成治疗而中止研究或未能完成全部检查项目，未遵从用药要求，无良好依从性者。(2)有应用可能影响疗效的其他药物。(3)病例资料缺失未完善，无法评定其疗效者。(4)观察中自然脱离。随机分为对照组和观察组各30例。其中对照组男16例，女14例，年龄47～78岁，平均(62±10)岁。观察组男17例，女13例，年龄45～75岁，平均(60±11)岁。两组患者年龄、性别等比较，差异无统计学意义(P>0.05)。两组入组前CID的分级秩和检验后差异无统计学意义(Z=-0.108，P=0.914)，见表1。入选患者知情同意参加本研究，签署知情同意书。, http://www.100md.com(吴刚 袁兴石 王进富)
【关键词】 化疗相关性腹泻 甘草泻心汤 穴位贴敷
[Abstract] Objective： To observe the clinical efficacy of Gancao Xiexin Tang combined with acupoint application for the treatment of chemotherapy induced diarrhea. Method： All the cases to be chosen were randomly divided into two groups. The control group was given routine treatment with Octreotide+Bifidobacterium， while the observation group was given Gancao Xiexin Tang and acupoint application on the basis of the control group， and the difference of treatment effect was observed between the two groups. Result： The thirty patients in the control group， 5 cases were markedly effective， 17 cases were effective， 8 cases were ineffective， and the total effective rate was 73.34%. The thirty patients in the observation group， 8 cases were markedly effective， 20 cases were effective， 2 cases were ineffective， and the total effective rate was 93.34%. The difference was significant (P<0.05). Conclusion： On the basis of conventional treatment， Gancao Xiexin Tang combined with acupoint application can improve the symptoms of chemotherapy induced diarrhea， decrease the number of diarrhea， reduce the general conditions and enhance the survivability on chemotherapy.
[Key words] Chemotherapy induced diarrhea Gancao Xiexin Tang Acupoint application
First-author’s address： Yancheng Dafeng Traditional Chinese Medicine Hospital， Yancheng 224100， China
近些年來由于生存环境的不断恶化及生活方式的急剧转变，恶性肿瘤的发病率不断增加，极大地威胁着人们健康。化疗作为恶性肿瘤治疗的重要手段之一，在控制癌细胞生长或杀死癌细胞活性的同时，对机体正常组织也起到不可避免的毒害作用，化疗相关性腹泻(CID)是其中常见的不良反应之一[1]。若未能妥善处理则可致机体电解质紊乱，肾素、血容量降低，出现休克甚至危及生命。临床上常规应用奥曲肽联合双歧杆菌治疗CID，虽疗效肯定，但仍有部分患者无明显好转，笔者尝试常规治疗上加用甘草泻心汤加减口服联合穴位贴敷治疗化疗相关性腹泻，收到不错的治疗效果，现作如下总结。
1 资料与方法
1.1 一般资料
研究对象为2013年10月-2018年10月笔者所在医院各类恶性肿瘤化疗期间出现腹泻症状的60例患者，肿瘤的分期与类别不限，纳入标准：(1)经细胞学或病理学检查诊断为恶性肿瘤，患者KPS评分>60分。(2)预计生存期大于3个月。(3)拟行化疗方案至少2周期的化疗患者。(4)依从性较好，可随访。排除标准：(1)在化疗前有慢性腹泻病史(大便次数>3次/d)。(2)合并有消化道出血、严重的电解质紊乱、急性或亚急性肠梗阻、酸碱失衡。(3)化疗前3个月使用抗生素或正在接受抗生素治疗>1周。入组病例出现以下情况者考虑剔除：(1)因故未能坚持完成治疗而中止研究或未能完成全部检查项目，未遵从用药要求，无良好依从性者。(2)有应用可能影响疗效的其他药物。(3)病例资料缺失未完善，无法评定其疗效者。(4)观察中自然脱离。随机分为对照组和观察组各30例。其中对照组男16例，女14例，年龄47～78岁，平均(62±10)岁。观察组男17例，女13例，年龄45～75岁，平均(60±11)岁。两组患者年龄、性别等比较，差异无统计学意义(P>0.05)。两组入组前CID的分级秩和检验后差异无统计学意义(Z=-0.108，P=0.914)，见表1。入选患者知情同意参加本研究，签署知情同意书。, http://www.100md.com(吴刚 袁兴石 王进富)
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